Isolation of lingzhifuran A and lingzhilactones D-F from Ganoderma lucidum as specific Smad3 phosphorylation inhibitors and total synthesis of lingzhifuran

doi:10.1039/c6ra17900b

	Isolation of lingzhifuran A and lingzhilactones D-F from Ganoderma lucidum as specific Smad3 phosphorylation inhibitors and total synthesis of lingzhifuran
	Ding, Wei-Yi 1,2; Ai, Jun 3; Wang, Xin-Long 1; Qiu, Fayang G.4,5; Lv, Qing 1; Fang, Ping 1; Hou, Fan-Fan 3; Yan, Yong-Ming 1; Cheng, Yong-Xian 1
	2016
发表期刊	RSC ADVANCES
卷号	6 期号:81 页码:77887-77897
摘要	Lingzhifuran A (1) and lingzhilactones D-F (2-4), four new phenolic meroterpenoids were isolated from the fruiting bodies of Ganoderma lucidum. Their structures were identified by spectroscopic data. Chiral HPLC analysis indicates the racemic nature of 2-4. Chiral separation followed by X-ray diffraction analysis discloses the absolute configuration of (-)-2. Compounds 1 and 2 could selectively inhibit TGF-beta 1-induced Smad3 phosphorylation in rat renal tubular epithelial cells, representing novel scaffolds of selective Smad3 activation inhibitors. Total synthesis accompanied by in vivo rodent experiments reveals antifibrotic activities of 1 against kidney fibrosis. Finally, a plausible biosynthetic pathway for 1 was proposed.
DOI	10.1039/c6ra17900b
收录类别	SCI
语种	英语
WOS记录号	WOS:000382482200085
引用统计	被引频次：16[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/33611
专题	植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China 2.Univ Chinese Acad Sci, Yuquan Rd 19, Beijing 100049, Peoples R China 3.Southern Med Univ, Nanfang Hosp, Div Nephrol, State Key Lab Organ Failure Res,Natl Clin Res Ctr, Guangzhou 510515, Guangdong, Peoples R China 4.Chinese Acad Sci, Guangzhou Inst Biomed & Hlth, Lab Mol Engn, Guangzhou 510530, Guangdong, Peoples R China 5.Chinese Acad Sci, Guangzhou Inst Biomed & Hlth, Lab Nat Prod Synth, Guangzhou 510530, Guangdong, Peoples R China
推荐引用方式 GB/T 7714	Ding, Wei-Yi,Ai, Jun,Wang, Xin-Long,et al. Isolation of lingzhifuran A and lingzhilactones D-F from Ganoderma lucidum as specific Smad3 phosphorylation inhibitors and total synthesis of lingzhifuran[J]. RSC ADVANCES,2016,6(81):77887-77897.
APA	Ding, Wei-Yi.,Ai, Jun.,Wang, Xin-Long.,Qiu, Fayang G..,Lv, Qing.,...&Cheng, Yong-Xian.(2016).Isolation of lingzhifuran A and lingzhilactones D-F from Ganoderma lucidum as specific Smad3 phosphorylation inhibitors and total synthesis of lingzhifuran.RSC ADVANCES,6(81),77887-77897.
MLA	Ding, Wei-Yi,et al."Isolation of lingzhifuran A and lingzhilactones D-F from Ganoderma lucidum as specific Smad3 phosphorylation inhibitors and total synthesis of lingzhifuran".RSC ADVANCES 6.81(2016):77887-77897.

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