| Brain-wide map of projections from mice ventral subiculum | |
Tang, He1,2; Wu, Gui-Sheng1 ; Xie, Jing1,2; He, Xiaobin3; Deng, Ke1; Wang, Huadong3; Xu, Fuqiang3,4; Luo, Huai-Rong1
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| 2016-08-26 | |
| 发表期刊 | NEUROSCIENCE LETTERS
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| 卷号 | 629页码:171-179 |
| 摘要 | The hippocampal formation plays a critical role in episodic memory formation and spatial navigation. Within the hippocampus, the subiculum is considered to be a hub connecting the hippocampal formation to the remainder of the brain. There are functional differences between the dorsal and ventral part of subiculum, while the ventral subiculum (vSub) plays a role in anxiety, stress and emotion. In the present study, we examined the projection of the ventral subiculum to the whole brain in mice by using a modified herpes simplex virus 1 strain H129 with an inserted fluorescent protein gene. In our experiments, the modified H129 transits the primary-order, second-order, and third-order neuronal projections at 36-44, 52-60 and 68-76 h after inoculation in mice, respectively. Our data revealed that vSub directly projects to the medial entorhinal cortex, amygdalohippocampal area, anterodorsal thalamic nucleus, medial hypothalamus, supramammillary nucleus, medial septal nucleus and adjacent diagonal band, the connections between median raphe nucleus and interpeduncular nucleus in brain stem, while ventral prefrontal cortex, laterodorsal tegmental nucleus and locus coeruleus receives second-order projections from vSub. Our data would help further understanding the functional connections of vSub with other brain regions. (C) 2016 Elsevier Ireland Ltd. All rights reserved. |
| 关键词 | Hippocampal Formation Ventral Subiculum Herpes Simplex Virus Neural Circuits Brain Map |
| DOI | 10.1016/j.neulet.2016.07.014 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000382409000031 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/33603 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, 134 Lanhei Rd, Kunming 650201, Yunnan, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100039, Peoples R China 3.Chinese Acad Sci, Wuhan Inst Phys & Math, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan 430071, Peoples R China 4.Wuhan Natl Lab Optoelect, Wuhan 430074, Peoples R China |
| 推荐引用方式 GB/T 7714 | Tang, He,Wu, Gui-Sheng,Xie, Jing,et al. Brain-wide map of projections from mice ventral subiculum[J]. NEUROSCIENCE LETTERS,2016,629:171-179. |
| APA | Tang, He.,Wu, Gui-Sheng.,Xie, Jing.,He, Xiaobin.,Deng, Ke.,...&Luo, Huai-Rong.(2016).Brain-wide map of projections from mice ventral subiculum.NEUROSCIENCE LETTERS,629,171-179. |
| MLA | Tang, He,et al."Brain-wide map of projections from mice ventral subiculum".NEUROSCIENCE LETTERS 629(2016):171-179. |
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| tang2016.pdf（4167KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | 浏览 下载 | |
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