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题名: Phytochemical Investigation and Cytotoxic Evaluation of the Components of the Medicinal Plant Ligularia atroviolacea
作者: Wang, Xiaoyu1; Sun, Lianli1; Huang, Kexin2; Shi, Shuyun3; Zhang, Lijuan1; Xu, Juanhua1; null(彭华)4; Sun, Xianfeng4; Wang, Liwei1; Wu, Xiumei2; Zhao, Yu1; Li, Xiaokun2; Stockigt, Joachim1; Qu, Jia2
刊名: CHEMISTRY & BIODIVERSITY
英文摘要: A phytochemical investigation of the roots of Ligularia atroviolacea resulted in the isolation of 24 compounds including seven new eremophilanoids named eremophila-3,7(11),8-triene-12,8;14,6 alpha-diolide (1), 3 beta-(angeloyloxy)eremophil-7(11)-en-12,8 beta-olid-14-oic acid (2), 1 alpha-chloro-10 beta-hydroxy-6 beta-(2-methylpropanoyloxy)-9-oxo-7,8-furoeremophilane (3), (10 beta H)-8-oxoeremophila-3(4),6(7)-diene-12,14-dioic acid (4), (10 alpha H)-8-oxoeremophila-3(4),6(7)-diene-12,14-dioic acid (5), 8 beta-[eremophila-3',7'(11')-diene-12',8'alpha;14',6'alpha-diolide]eremophila-3,7(11)-diene-12,8 alpha;14,6 alpha-diolide (6), and ligulatrovine A (7), eleven known eremophilanoids, 8-18, four steroids, one glucose derivative, and one fatty acid. The structures of these compounds were elucidated by spectroscopic methods including 2D-NMR experiments. The structure of 3 was also established by an X-ray diffraction study. The in vitro cytotoxicity evaluation of selected compounds was performed on seven cultured tumor cell lines, i.e., KB, BEL-7404, A549, HL-60, HeLa, CNE, and P-388D1. The preliminary taxonomy of this species was also discussed, and the possible biogenesis of a dimer possessing a new noreremophilanoid type skeleton, 7, is presented in a preliminary form.
出版日期: 2009
卷号: 6, 期号:7, 页码:1053-1065
语种: 英语
收录类别: SCI
学科分类: Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
ISSN号: 1612-1872
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/3144
Appears in Collections:中国科学院东亚植物多样性与生物地理学重点实验室_期刊论文

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作者单位: 1.Zhejiang Univ, Coll Pharmaceut Sci, Dept Tradit Chinese Med & Nat Drug Res, Hangzhou 310031, Zhejiang, Peoples R China
2.Wenzhou Med Coll, Sch Pharm, Key Lab So Zhejiang TCM R&D, Wenzhou 325035, Peoples R China
3.Cent S Univ, Sch Chem & Chem Engn, Changsha 410083, Peoples R China
4.Chinese Acad Sci, Kunming Inst Bot, Kunming 650204, Peoples R China

Recommended Citation:
Wang, XY; Sun, LL; Huang, KX; Shi, SY; Zhang, LJ; Xu, JH; Peng, H; Sun, XF; Wang, LW; Wu, XM; Zhao, Y; Li, XK; Stockigt, J; Qu, J.Phytochemical Investigation and Cytotoxic Evaluation of the Components of the Medicinal Plant Ligularia atroviolacea,CHEMISTRY & BIODIVERSITY,2009,6(7):1053-1065
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