| Cytotoxic alkaloids from the bulbs of Fritillaria hupehensis | |
Zhang, Yong-Hui1; Yang, Xi-Liang1; Zhang, Peng1; Zhou, Xue-Feng1; Ruan, Han-Li1; Pi, Hui-Fang1; Wu, Ji-Zhou1; Sun, Han-Dong2
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| 通讯作者 | ywjz@mails.tjmu.edu.cn |
| 2008 | |
| 发表期刊 | CHEMISTRY & BIODIVERSITY
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| ISSN | 1612-1872 |
| 卷号 | 5期号:2页码:259-266 |
| 摘要 | Phytochemical investigation of the bulbs of Fritillaria hupehensis resulted in the isolation and structural elucidation of four new steroidal penta- and hexacyclic veratraman- and cevan-based alkaloids, respectively, compounds 1-4. They were obtained together with the known constituents ebeinine (5) and zhebeinine (6), which were isolated for the first time from this plant. The structures of the new isolates were established by spectroscopic and mass-spectrometric analyses, in combination with chemical methods. All compounds were assayed for their cytotoxic effects towards HeLa and HepG2 cell lines. Compounds 1 and 2 showed significant inhibitory effects against both types of tumor cells, with IC50 values in the range 2.52-0.23 mu M, similar as those for 5-fluorouracil used as positive control. |
| 学科领域 | Biochemistry & Molecular Biology ; Chemistry, Multidisciplinary |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000253749100004 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/2945 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Huazhong Univ Sci & Technol, Tongji Med Coll, Fac Pharmaceut Sci, Wuhan 430030, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, Kunming 650204, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Yong-Hui,Yang, Xi-Liang,Zhang, Peng,et al. Cytotoxic alkaloids from the bulbs of Fritillaria hupehensis[J]. CHEMISTRY & BIODIVERSITY,2008,5(2):259-266. |
| APA | Zhang, Yong-Hui.,Yang, Xi-Liang.,Zhang, Peng.,Zhou, Xue-Feng.,Ruan, Han-Li.,...&Sun, Han-Dong.(2008).Cytotoxic alkaloids from the bulbs of Fritillaria hupehensis.CHEMISTRY & BIODIVERSITY,5(2),259-266. |
| MLA | Zhang, Yong-Hui,et al."Cytotoxic alkaloids from the bulbs of Fritillaria hupehensis".CHEMISTRY & BIODIVERSITY 5.2(2008):259-266. |
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