| Screening and docking studies of natural phenolic inhibitors of carbonic anhydrase II | |
HuoQiang, Huang1,2; Pan XuLin1; Ji ChangJiu1,2; Zeng GuangZhi1; Jiang LiHua1; Fu Xiang1; Liu JiKai1; Hao XiaoJiang1 ; Zhang YingJun1; Tan NingHua1
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| 2009-03-01 | |
| 发表期刊 | SCIENCE IN CHINA SERIES B-CHEMISTRY
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| ISSN | 1006-9291 |
| 卷号 | 52期号:3页码:332-337 |
| 摘要 | Carbonic anhydrase II (CA II) is an important enzyme complex with Zn(2+), which is involved in many physiological and pathological processes, such as calcification, glaucoma and tumorigenicity. In order to search for novel inhibitors of CA II, inhibition assay of carbonic anhydrase II was performed, by which seven natural phenolic compounds, including four phenolics (grifolin, 4-O-methyl-grifolic acid, grifolic acid, and isovanillic acid) and three flavones (eriodictyol, quercetin and puerin A), showed inhibitory activities against CA II with IC(50)s in the range of 6.37-71.73 mu mol/L. Grifolic acid is the most active one with IC(50) of 6.37 (mu)mol/L. These seven phenolic compounds were proved to be novel natural carbonic anhydrase II inhibitors, which were obtained in flexible docking study with GOLD 3.0 software. Results indicated that the aliphatic chain and polar groups of hydroxyl and carboxyl are important to their inhibitory activities, providing a new insight into study on CA II potent inhibitors. |
| 关键词 | Carbonic Anhydrase Ii Natural Inhibitors Screening Docking |
| 学科领域 | Chemistry, Multidisciplinary |
| DOI | 10.1007/s11426-008-0133-1 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000264886800013 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/2917 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | HuoQiang, Huang,Pan XuLin,Ji ChangJiu,et al. Screening and docking studies of natural phenolic inhibitors of carbonic anhydrase II[J]. SCIENCE IN CHINA SERIES B-CHEMISTRY,2009,52(3):332-337. |
| APA | HuoQiang, Huang.,Pan XuLin.,Ji ChangJiu.,Zeng GuangZhi.,Jiang LiHua.,...&Tan NingHua.(2009).Screening and docking studies of natural phenolic inhibitors of carbonic anhydrase II.SCIENCE IN CHINA SERIES B-CHEMISTRY,52(3),332-337. |
| MLA | HuoQiang, Huang,et al."Screening and docking studies of natural phenolic inhibitors of carbonic anhydrase II".SCIENCE IN CHINA SERIES B-CHEMISTRY 52.3(2009):332-337. |
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