| Synthesis and Biological Testing of Novel Glucosylated Epigallocatechin Gallate (EGCG) Derivatives | |
Zhang, Xin1,2,3; Wang, Jing1,2; Hu, Jiang-Miao4 ; Huang, Ye-Wei1,2; Wu, Xiao-Yun1,2,3; Zi, Cheng-Ting1,2,3; Wang, Xuan-Jun1,2,3,5; Sheng, Jun1,2,5
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| 2016-05-01 | |
| 发表期刊 | MOLECULES
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| 卷号 | 21期号:5页码:1 |
| 摘要 | Epigallocatechin gallate (EGCG) is the most abundant component of green tea catechins and has strong physiological activities. In this study, two novel EGCG glycosides (EGCG-G1 and EGCG-G2) were chemoselectively synthesized by a chemical modification strategy. Each of these EGCG glycosides underwent structure identification, and the structures were assigned as follows: epigallocatechin gallate-4 ''-O-beta-D-glucopyranoside (EGCG-G1, 2) and epigallocatechin gallate-4 1,4 ''-O-beta-D-gluco-pyranoside (EGCG-G2, 3). The EGCG glycosides were evaluated for their anticancer activity in vitro against two human breast cell lines (MCF-7 and MDA-MB-231) using MTT assays. The inhibition rate of EGCG glycosides (EGCG-G1 and EGCG-G2) is not obvious. The EGCG glycosides are more stable than EGCG in aqueous solutions, but exhibited decreasing antioxidant activity in the DPPH radical-scavenging assay (EGCG > EGCG-G2 > EGCG-G1). Additionally, the EGCG glycosides exhibited increased water solubility: EGCG-G2 and EGCG-G1 were 15 and 31 times as soluble EGCG, respectively. The EGCG glycosides appear to be useful, and further studies regarding their biological activity are in progress. |
| 关键词 | Epigallocatechin Gallate (Egcg) Glycosides Anticancer Activity Dpph Synthesis |
| DOI | 10.3390/molecules21050620 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000380241600084 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/28518 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Yunnan Agr Univ, Key Lab Pu Er Tea Sci, Minist Educ, Kunming 650201, Peoples R China 2.Tea Res Ctr Yunnan, Kunming 650201, Peoples R China 3.Yunnan Agr Univ, Pu Er Tea Acad, Kunming 650201, Peoples R China 4.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China 5.State Key Lab Conservat & Utilizat Bioresources Y, Kunming 650201, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Xin,Wang, Jing,Hu, Jiang-Miao,et al. Synthesis and Biological Testing of Novel Glucosylated Epigallocatechin Gallate (EGCG) Derivatives[J]. MOLECULES,2016,21(5):1. |
| APA | Zhang, Xin.,Wang, Jing.,Hu, Jiang-Miao.,Huang, Ye-Wei.,Wu, Xiao-Yun.,...&Sheng, Jun.(2016).Synthesis and Biological Testing of Novel Glucosylated Epigallocatechin Gallate (EGCG) Derivatives.MOLECULES,21(5),1. |
| MLA | Zhang, Xin,et al."Synthesis and Biological Testing of Novel Glucosylated Epigallocatechin Gallate (EGCG) Derivatives".MOLECULES 21.5(2016):1. |
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| molecules-21-00620.p（1410KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | 浏览 下载 | |
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