Synthesis and Biological Testing of Novel Glucosylated Epigallocatechin Gallate (EGCG) Derivatives
Zhang, Xin1,2,3; Wang, Jing1,2; Hu, Jiang-Miao4; Huang, Ye-Wei1,2; Wu, Xiao-Yun1,2,3; Zi, Cheng-Ting1,2,3; Wang, Xuan-Jun1,2,3,5; Sheng, Jun1,2,5
2016-05-01
发表期刊MOLECULES
卷号21期号:5页码:1
摘要Epigallocatechin gallate (EGCG) is the most abundant component of green tea catechins and has strong physiological activities. In this study, two novel EGCG glycosides (EGCG-G1 and EGCG-G2) were chemoselectively synthesized by a chemical modification strategy. Each of these EGCG glycosides underwent structure identification, and the structures were assigned as follows: epigallocatechin gallate-4 ''-O-beta-D-glucopyranoside (EGCG-G1, 2) and epigallocatechin gallate-4 1,4 ''-O-beta-D-gluco-pyranoside (EGCG-G2, 3). The EGCG glycosides were evaluated for their anticancer activity in vitro against two human breast cell lines (MCF-7 and MDA-MB-231) using MTT assays. The inhibition rate of EGCG glycosides (EGCG-G1 and EGCG-G2) is not obvious. The EGCG glycosides are more stable than EGCG in aqueous solutions, but exhibited decreasing antioxidant activity in the DPPH radical-scavenging assay (EGCG > EGCG-G2 > EGCG-G1). Additionally, the EGCG glycosides exhibited increased water solubility: EGCG-G2 and EGCG-G1 were 15 and 31 times as soluble EGCG, respectively. The EGCG glycosides appear to be useful, and further studies regarding their biological activity are in progress.
关键词Epigallocatechin Gallate (Egcg) Glycosides Anticancer Activity Dpph Synthesis
DOI10.3390/molecules21050620
收录类别SCI
语种英语
WOS记录号WOS:000380241600084
引用统计
被引频次:34[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/28518
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Yunnan Agr Univ, Key Lab Pu Er Tea Sci, Minist Educ, Kunming 650201, Peoples R China
2.Tea Res Ctr Yunnan, Kunming 650201, Peoples R China
3.Yunnan Agr Univ, Pu Er Tea Acad, Kunming 650201, Peoples R China
4.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
5.State Key Lab Conservat & Utilizat Bioresources Y, Kunming 650201, Peoples R China
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Zhang, Xin,Wang, Jing,Hu, Jiang-Miao,et al. Synthesis and Biological Testing of Novel Glucosylated Epigallocatechin Gallate (EGCG) Derivatives[J]. MOLECULES,2016,21(5):1.
APA Zhang, Xin.,Wang, Jing.,Hu, Jiang-Miao.,Huang, Ye-Wei.,Wu, Xiao-Yun.,...&Sheng, Jun.(2016).Synthesis and Biological Testing of Novel Glucosylated Epigallocatechin Gallate (EGCG) Derivatives.MOLECULES,21(5),1.
MLA Zhang, Xin,et al."Synthesis and Biological Testing of Novel Glucosylated Epigallocatechin Gallate (EGCG) Derivatives".MOLECULES 21.5(2016):1.
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