A sodium channel inhibitor ISTX-I with a novel structure provides a new hint at the evolutionary link between two toxin folds

doi:10.1038/srep29691

	A sodium channel inhibitor ISTX-I with a novel structure provides a new hint at the evolutionary link between two toxin folds
	Rong, Mingqiang; Liu, Jiangxin; Zhang, Meilin; Wang, Gan; Zhao, Gang; Wang, Guodong; Zhang, Yaping; Hu, Kaifeng; Lai, Ren
	2016-07-13
发表期刊	SCIENTIFIC REPORTS
卷号	6
摘要	Members of arachnida, such as spiders and scorpions, commonly produce venom with specialized venom glands, paralyzing their prey with neurotoxins that specifically target ion channels. Two well-studied motifs, the disulfide-directed hairpin (DDH) and the inhibitor cystine knot motif (ICK), are both found in scorpion and spider toxins. As arachnids, ticks inject a neurotoxin-containing cocktail from their salivary glands into the host to acquire a blood meal, but peptide toxins acting on ion channels have not been observed in ticks. Here, a new neurotoxin (ISTX-I) that acts on sodium channels was identified from the hard tick Ixodes scapularis and characterized. ISTX-I exhibits a potent inhibitory function with an IC50 of 1.6 mu M for sodium channel Nav1.7 but not other sodium channel subtypes. ISTX-I adopts a novel structural fold and is distinct from the canonical ICK motif. Analysis of the ISTX-I, DDH and ICK motifs reveals that the new ISTX-I motif might be an intermediate scaffold between DDH and ICK, and ISTX-I is a clue to the evolutionary link between the DDH and ICK motifs. These results provide a glimpse into the convergent evolution of neurotoxins from predatory and blood-sucking arthropods.
DOI	10.1038/srep29691
收录类别	SCI
语种	英语
WOS记录号	WOS:000379580300001
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/28468
专题	植物化学与西部植物资源持续利用国家重点实验室
推荐引用方式 GB/T 7714	Rong, Mingqiang,Liu, Jiangxin,Zhang, Meilin,et al. A sodium channel inhibitor ISTX-I with a novel structure provides a new hint at the evolutionary link between two toxin folds[J]. SCIENTIFIC REPORTS,2016,6.
APA	Rong, Mingqiang.,Liu, Jiangxin.,Zhang, Meilin.,Wang, Gan.,Zhao, Gang.,...&Lai, Ren.(2016).A sodium channel inhibitor ISTX-I with a novel structure provides a new hint at the evolutionary link between two toxin folds.SCIENTIFIC REPORTS,6.
MLA	Rong, Mingqiang,et al."A sodium channel inhibitor ISTX-I with a novel structure provides a new hint at the evolutionary link between two toxin folds".SCIENTIFIC REPORTS 6(2016).

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