| Two New Oleanane-type Triterpenoids from Methanolyzed Saponins of Momordica cochinchinensis | |
Fan, Rong1,2; Cheng, Rong-Rong1 ; Zhu, Hong-Tao1; Wang, Dong1; Yang, Chong-Ren1; Xu, Min1; Zhang, Ying-Jun1
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| 2016-06-01 | |
| 发表期刊 | NATURAL PRODUCT COMMUNICATIONS
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| 卷号 | 11期号:6页码:725-728 |
| 摘要 | Two new oleanane-type triterpenoid saponins (1 and 2) were isolated from the methanolyzed total saponins of the seeds of Momordica cochinchinensis (Lour.) Spreng, together with 16 known compounds (3-18). Their structures were elucidated on the basis of detailed spectroscopic, including 1D and 2D NMR, mass spectrometric, methanolysis and LC-MS analysis. All the isolates were tested for their cytotoxic activities against five human cancer cell lines (HL-60, SMMC-7721, PANC-1, A-549, and SW-480) and the glucose uptake activity. The known compound 6 exhibited toxic effects against HL-60 with an IC50 value of 18.1 mu M, while 10 showed cytotoxicity against SMMC-7721 and A-549 cell lines, with IC50 values of 34.4 and 32.8 mu M, respectively. In addition, the new compound 2 showed glucose uptake activity with a glucose consumption value of 0.29 mu M at 10 mu M concentration. |
| 关键词 | Momordica Cochinchinensis Oleanane-type Triterpenoid Saponins Cytotoxic Activity Glucose Uptake Activity |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000379631600007 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/28462 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China 2.Yunnan Univ Tradit Chinese Med, Kunming 650500, Peoples R China |
| 推荐引用方式 GB/T 7714 | Fan, Rong,Cheng, Rong-Rong,Zhu, Hong-Tao,et al. Two New Oleanane-type Triterpenoids from Methanolyzed Saponins of Momordica cochinchinensis[J]. NATURAL PRODUCT COMMUNICATIONS,2016,11(6):725-728. |
| APA | Fan, Rong.,Cheng, Rong-Rong.,Zhu, Hong-Tao.,Wang, Dong.,Yang, Chong-Ren.,...&Zhang, Ying-Jun.(2016).Two New Oleanane-type Triterpenoids from Methanolyzed Saponins of Momordica cochinchinensis.NATURAL PRODUCT COMMUNICATIONS,11(6),725-728. |
| MLA | Fan, Rong,et al."Two New Oleanane-type Triterpenoids from Methanolyzed Saponins of Momordica cochinchinensis".NATURAL PRODUCT COMMUNICATIONS 11.6(2016):725-728. |
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