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题名: UPLC-QTOFMS(E)-Guided Dereplication of the Endangered Chinese Species Garcinia paucinervis to Identify Additional Benzophenone Derivatives
作者: Li, Ping1; Senthilkumar, Harini Anandhi4; Figueroa, Mario5; Wu, Shi-Biao2; Fata, Jimmie E.3, 4; Kennelly, Edward J.1, 2, 4; Long, Chunlin1, 6
刊名: JOURNAL OF NATURAL PRODUCTS
英文摘要: A number of Garcinia species accumulate benzophenone derivatives that may be useful for the treatment of breast cancer. The dereplication of new benzophenone derivatives from Garcinia species is challenging due to the occurrence of multiple isomers and the known compounds found in their extracts. In the current study, a strategy is described using the UPLC-QTOFMS(E) technique to identify tentatively the known and uncharacterized benzophenones of interest based upon the characteristic fragmentation ions. Several UPLC-QTOFMS peaks (a-ee) appeared to contain benzophenone derivatives, and 12 of these peaks contained compounds with MS ionization profiles not consistent with previously identified compounds from the seeds of Garcinia paucinervis, an endangered Chinese species. The targeted isolation of unidentified compounds of interest afforded five new benzophenones, paucinones E-I (1-5), which were determined by MS and NMR analysis and ECD spectroscopy. These compounds were evaluated for cytotoxicity against three breast cancer cell lines inclusive of MDA-MB-231, SKBR3, and MCF-7. These results indicate that the UPLC-QTOFMS(E)-guided isolation procedure is an efficient strategy for isolating new benzophenones from Garcinia species.
出版日期: 2016-06-01
卷号: 79, 期号:6, 页码:1619-1627
DOI标识: 10.1021/acs.jnatprod.6b00186
语种: 英语
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内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/26296
Appears in Collections:离退休_期刊论文

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作者单位: 1.Minzu Univ China, Coll Life & Environm Sci, Beijing 100081, Peoples R China
2.CUNY, Lehman Coll, Dept Biol Sci, Bronx, NY 10468 USA
3.CUNY Coll Staten Isl, Dept Biol Sci, Staten Isl, NY 10314 USA
4.CUNY, Grad Ctr, Biochem Biol & Chem PhD Programs, New York, NY 10016 USA
5.Univ Nacl Autonoma Mexico, Fac Quim, Mexico City 04510, DF, Mexico
6.Chinese Acad Sci, Kunming Inst Bot, Kunming 650201, Peoples R China
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