UPLC-QTOFMS(E)-Guided Dereplication of the Endangered Chinese Species Garcinia paucinervis to Identify Additional Benzophenone Derivatives

doi:10.1021/acs.jnatprod.6b00186

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	UPLC-QTOFMS(E)-Guided Dereplication of the Endangered Chinese Species Garcinia paucinervis to Identify Additional Benzophenone Derivatives
	Li, Ping 1; Senthilkumar, Harini Anandhi 4; Figueroa, Mario 5; Wu, Shi-Biao 2; Fata, Jimmie E.3,4; Kennelly, Edward J.1,2,4; Long, Chunlin 1,6
	2016-06-01
发表期刊	JOURNAL OF NATURAL PRODUCTS
卷号	79 期号:6 页码:1619-1627
摘要	A number of Garcinia species accumulate benzophenone derivatives that may be useful for the treatment of breast cancer. The dereplication of new benzophenone derivatives from Garcinia species is challenging due to the occurrence of multiple isomers and the known compounds found in their extracts. In the current study, a strategy is described using the UPLC-QTOFMS(E) technique to identify tentatively the known and uncharacterized benzophenones of interest based upon the characteristic fragmentation ions. Several UPLC-QTOFMS peaks (a-ee) appeared to contain benzophenone derivatives, and 12 of these peaks contained compounds with MS ionization profiles not consistent with previously identified compounds from the seeds of Garcinia paucinervis, an endangered Chinese species. The targeted isolation of unidentified compounds of interest afforded five new benzophenones, paucinones E-I (1-5), which were determined by MS and NMR analysis and ECD spectroscopy. These compounds were evaluated for cytotoxicity against three breast cancer cell lines inclusive of MDA-MB-231, SKBR3, and MCF-7. These results indicate that the UPLC-QTOFMS(E)-guided isolation procedure is an efficient strategy for isolating new benzophenones from Garcinia species.
DOI	10.1021/acs.jnatprod.6b00186
收录类别	SCI
语种	英语
WOS记录号	WOS:000378758200017
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/26296
专题	离退休
作者单位	1.Minzu Univ China, Coll Life & Environm Sci, Beijing 100081, Peoples R China 2.CUNY, Lehman Coll, Dept Biol Sci, Bronx, NY 10468 USA 3.CUNY Coll Staten Isl, Dept Biol Sci, Staten Isl, NY 10314 USA 4.CUNY, Grad Ctr, Biochem Biol & Chem PhD Programs, New York, NY 10016 USA 5.Univ Nacl Autonoma Mexico, Fac Quim, Mexico City 04510, DF, Mexico 6.Chinese Acad Sci, Kunming Inst Bot, Kunming 650201, Peoples R China
推荐引用方式 GB/T 7714	Li, Ping,Senthilkumar, Harini Anandhi,Figueroa, Mario,et al. UPLC-QTOFMS(E)-Guided Dereplication of the Endangered Chinese Species Garcinia paucinervis to Identify Additional Benzophenone Derivatives[J]. JOURNAL OF NATURAL PRODUCTS,2016,79(6):1619-1627.
APA	Li, Ping.,Senthilkumar, Harini Anandhi.,Figueroa, Mario.,Wu, Shi-Biao.,Fata, Jimmie E..,...&Long, Chunlin.(2016).UPLC-QTOFMS(E)-Guided Dereplication of the Endangered Chinese Species Garcinia paucinervis to Identify Additional Benzophenone Derivatives.JOURNAL OF NATURAL PRODUCTS,79(6),1619-1627.
MLA	Li, Ping,et al."UPLC-QTOFMS(E)-Guided Dereplication of the Endangered Chinese Species Garcinia paucinervis to Identify Additional Benzophenone Derivatives".JOURNAL OF NATURAL PRODUCTS 79.6(2016):1619-1627.

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