New Cytotoxic Tigliane Diterpenoids from Croton caudatus
Chen, Ying-Ying1,2; Yang, Kun-Xian3; Yang, Xing-Wei1; Khan, Afsar1,4; Liu, Lu1,2; Wang, Bei1,2; Zhao, Yun-Li1; Liu, Ya-Ping1; Li, Yan1; Luo, Xiao-Dong1
2016-05-01
Source PublicationPLANTA MEDICA
Volume82Issue:8Pages:729-733
AbstractThree new tigliane-type diterpenoids were isolated from the methanolic extract of the twigs and leaves of Croton caudatus, trivially named crotusins A-C (1-3). The structures of compounds 1-3 were elucidated on the basis of extensive spectral methods. These new compounds were highly oxygenated and heavily substituted. Cytotoxic activity against five human tumor cell lines was assessed for compounds 1-3 of which compound 3 showed significant inhibitory activity with IC50 values ranging from 0.49 to 4.19 mu M against these cells, while crotusins A and B exhibited moderate activity.
KeywordCroton Caudatus Euphorbiaceae Tigliane Diterpenoid Cytotoxic Activity
DOI10.1055/s-0042-102539
Indexed BySCI
Language英语
WOS Research AreaPlant Sciences ; Pharmacology & Pharmacy ; Integrative & Complementary Medicine
WOS SubjectPlant Sciences ; Chemistry, Medicinal ; Integrative & Complementary Medicine ; Pharmacology & Pharmacy
WOS IDWOS:000377703700008
Citation statistics
Cited Times:10[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/26282
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, 132 Lanhei Rd, Kunming 650201, Peoples R China
2.Univ Chinese Acad Sci, Beijing, Peoples R China
3.First People Hosp Yunnan Prov, Kunming, Peoples R China
4.COMSATS Inst Informat Technol, Dept Chem, Abbottabad, Pakistan
Recommended Citation
GB/T 7714
Chen, Ying-Ying,Yang, Kun-Xian,Yang, Xing-Wei,et al. New Cytotoxic Tigliane Diterpenoids from Croton caudatus[J]. PLANTA MEDICA,2016,82(8):729-733.
APA Chen, Ying-Ying.,Yang, Kun-Xian.,Yang, Xing-Wei.,Khan, Afsar.,Liu, Lu.,...&Luo, Xiao-Dong.(2016).New Cytotoxic Tigliane Diterpenoids from Croton caudatus.PLANTA MEDICA,82(8),729-733.
MLA Chen, Ying-Ying,et al."New Cytotoxic Tigliane Diterpenoids from Croton caudatus".PLANTA MEDICA 82.8(2016):729-733.
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