(+/-)-Japonicols A-D, Acylphloroglucinol-Based Meroterpenoid Enantiomers with Anti-KSHV Activities from Hypericum japonicum
Hu, Linzhen1,2; Xue, Yongbo2; Zhang, Jinwen3; Zhu, Hucheng2; Chen, Chunmei2; Li, Xiao-Nain4; Liu, Junjun2; Wang, Zhenzhen2; Zhang, Yu1; Zhang, Yonghui2
2016-05-01
Source PublicationJOURNAL OF NATURAL PRODUCTS
Volume79Issue:5Pages:1322-1328
Abstract(+/-)-Japonicols A D (1a/1b-4a/4b), four pairs of new phloroglucinol-based terpenoid enantiomers, were isolated from Hypericum japonicum. Their absolute configurations were confirmed through comparison of their experimental and calculated electronic circular dichroism spectra and single -crystal X-ray diffraction analyses. Compounds 1a/1b, 2a/2b, and 3a/ 3b possess 2-oxabicyclo[3.3.1]nonane, pyrano[3,2-b]pyran, and benzo[b]cyclopenta[e]oxepine ring systems, respectively. The effects of the phloroglucinols on anti-Kaposi's sarcoma -associated herpesvirus were assessed, and 2a exhibited a moderate inhibitory effect, with an EC50 value of 8.75 mu M and a selectivity index of 16.06.
DOI10.1021/acs.jnatprod.5b01119
Indexed BySCI
Language英语
WOS Research AreaPlant Sciences ; Pharmacology & Pharmacy
WOS SubjectPlant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS IDWOS:000377150900013
Citation statistics
Cited Times:15[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/26266
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Wuhan 430022, Peoples R China
2.Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Pharm, Wuhan 430030, Hubei Province, Peoples R China
3.Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Wuhan 430030, Peoples R China
4.Chinese Acad Sci, Kunming Inst Bot, Kunming 650204, Peoples R China
Recommended Citation
GB/T 7714
Hu, Linzhen,Xue, Yongbo,Zhang, Jinwen,et al. (+/-)-Japonicols A-D, Acylphloroglucinol-Based Meroterpenoid Enantiomers with Anti-KSHV Activities from Hypericum japonicum[J]. JOURNAL OF NATURAL PRODUCTS,2016,79(5):1322-1328.
APA Hu, Linzhen.,Xue, Yongbo.,Zhang, Jinwen.,Zhu, Hucheng.,Chen, Chunmei.,...&Zhang, Yonghui.(2016).(+/-)-Japonicols A-D, Acylphloroglucinol-Based Meroterpenoid Enantiomers with Anti-KSHV Activities from Hypericum japonicum.JOURNAL OF NATURAL PRODUCTS,79(5),1322-1328.
MLA Hu, Linzhen,et al."(+/-)-Japonicols A-D, Acylphloroglucinol-Based Meroterpenoid Enantiomers with Anti-KSHV Activities from Hypericum japonicum".JOURNAL OF NATURAL PRODUCTS 79.5(2016):1322-1328.
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