| (+/-)-Japonicols A-D, Acylphloroglucinol-Based Meroterpenoid Enantiomers with Anti-KSHV Activities from Hypericum japonicum | |
Hu, Linzhen1,2; Xue, Yongbo2; Zhang, Jinwen3; Zhu, Hucheng2; Chen, Chunmei2; Li, Xiao-Nain4; Liu, Junjun2; Wang, Zhenzhen2; Zhang, Yu1 ; Zhang, Yonghui2
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| 2016-05-01 | |
| 发表期刊 | JOURNAL OF NATURAL PRODUCTS
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| 卷号 | 79期号:5页码:1322-1328 |
| 摘要 | (+/-)-Japonicols A D (1a/1b-4a/4b), four pairs of new phloroglucinol-based terpenoid enantiomers, were isolated from Hypericum japonicum. Their absolute configurations were confirmed through comparison of their experimental and calculated electronic circular dichroism spectra and single -crystal X-ray diffraction analyses. Compounds 1a/1b, 2a/2b, and 3a/ 3b possess 2-oxabicyclo[3.3.1]nonane, pyrano[3,2-b]pyran, and benzo[b]cyclopenta[e]oxepine ring systems, respectively. The effects of the phloroglucinols on anti-Kaposi's sarcoma -associated herpesvirus were assessed, and 2a exhibited a moderate inhibitory effect, with an EC50 value of 8.75 mu M and a selectivity index of 16.06. |
| DOI | 10.1021/acs.jnatprod.5b01119 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000377150900013 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/26266 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Wuhan 430022, Peoples R China 2.Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Pharm, Wuhan 430030, Hubei Province, Peoples R China 3.Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Wuhan 430030, Peoples R China 4.Chinese Acad Sci, Kunming Inst Bot, Kunming 650204, Peoples R China |
| 推荐引用方式 GB/T 7714 | Hu, Linzhen,Xue, Yongbo,Zhang, Jinwen,et al. (+/-)-Japonicols A-D, Acylphloroglucinol-Based Meroterpenoid Enantiomers with Anti-KSHV Activities from Hypericum japonicum[J]. JOURNAL OF NATURAL PRODUCTS,2016,79(5):1322-1328. |
| APA | Hu, Linzhen.,Xue, Yongbo.,Zhang, Jinwen.,Zhu, Hucheng.,Chen, Chunmei.,...&Zhang, Yonghui.(2016).(+/-)-Japonicols A-D, Acylphloroglucinol-Based Meroterpenoid Enantiomers with Anti-KSHV Activities from Hypericum japonicum.JOURNAL OF NATURAL PRODUCTS,79(5),1322-1328. |
| MLA | Hu, Linzhen,et al."(+/-)-Japonicols A-D, Acylphloroglucinol-Based Meroterpenoid Enantiomers with Anti-KSHV Activities from Hypericum japonicum".JOURNAL OF NATURAL PRODUCTS 79.5(2016):1322-1328. |
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