New cytotoxic lignan glycosides from Phyllanthus glaucus
Yu, Shan1,2; Lv, Jun-Jiang1; Zhao, Jian-Qiang1; Li, Yan1; Wang, Dong1; Yang, Chong-Ren1; Xu, Min1; Zhang, Ying-Jun1
2016
发表期刊NATURAL PRODUCT RESEARCH
卷号30期号:4页码:419-425
摘要During the process of exploring bioactive lead compounds from Phyllanthus species, two new glycosides including an arylnaphthalene lignan, diphyllin 4-O-alpha-L-arabinopyranosyl-(1 -> 3)-alpha-L-arabinopyranoside (1), and a phenolic compound, 3,4,5-trimethoxybenzyl alcohol 7-O-alpha-L-arabinofuranosyl-(1 -> 6)-beta-D-glucopyranoside (2), were isolated from the methanol extract of the whole plants of Phyllanthus glaucus Wall. ex Mull. Arg. In addition, 31 known compounds, including 19 lignan derivatives (3-21), four phenylpropanoids (22-25), seven simple phenolics (26-32) and one monoterpenoid (33) were obtained. Their structures were determined on the basis of the HR-ESI-MS, 1D and 2D NMR spectroscopic analysis, and pre-column derivative/chiral HPLC analysis in case of 1 for the absolute configurations. All these compounds were obtained from P. glaucus for the first time. Moreover, the known lignan glycoside, phyllanthusmin C (5) showed in vitro cytotoxicities against HL-60, MCF-7 and SW480 cells with IC50 values of 9.2 +/- 0.2, 19.2 +/- 1.7 and 20.5 +/- 0.9, respectively.
关键词Phyllanthus Glaucus Wall. Ex Mull. Arg Glycoside Arylnaphthalene Lignan Phenolics Cytotoxicity
DOI10.1080/14786419.2015.1023198
收录类别SCI
语种英语
WOS记录号WOS:000375841100007
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/26252
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Lanhei Rd 132, Kunming 650201, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
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Yu, Shan,Lv, Jun-Jiang,Zhao, Jian-Qiang,et al. New cytotoxic lignan glycosides from Phyllanthus glaucus[J]. NATURAL PRODUCT RESEARCH,2016,30(4):419-425.
APA Yu, Shan.,Lv, Jun-Jiang.,Zhao, Jian-Qiang.,Li, Yan.,Wang, Dong.,...&Zhang, Ying-Jun.(2016).New cytotoxic lignan glycosides from Phyllanthus glaucus.NATURAL PRODUCT RESEARCH,30(4),419-425.
MLA Yu, Shan,et al."New cytotoxic lignan glycosides from Phyllanthus glaucus".NATURAL PRODUCT RESEARCH 30.4(2016):419-425.
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