| New cytotoxic lignan glycosides from Phyllanthus glaucus | |
Yu, Shan1,2 ; Lv, Jun-Jiang1; Zhao, Jian-Qiang1; Li, Yan1; Wang, Dong1; Yang, Chong-Ren1; Xu, Min1; Zhang, Ying-Jun1
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| 2016 | |
| 发表期刊 | NATURAL PRODUCT RESEARCH
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| 卷号 | 30期号:4页码:419-425 |
| 摘要 | During the process of exploring bioactive lead compounds from Phyllanthus species, two new glycosides including an arylnaphthalene lignan, diphyllin 4-O-alpha-L-arabinopyranosyl-(1 -> 3)-alpha-L-arabinopyranoside (1), and a phenolic compound, 3,4,5-trimethoxybenzyl alcohol 7-O-alpha-L-arabinofuranosyl-(1 -> 6)-beta-D-glucopyranoside (2), were isolated from the methanol extract of the whole plants of Phyllanthus glaucus Wall. ex Mull. Arg. In addition, 31 known compounds, including 19 lignan derivatives (3-21), four phenylpropanoids (22-25), seven simple phenolics (26-32) and one monoterpenoid (33) were obtained. Their structures were determined on the basis of the HR-ESI-MS, 1D and 2D NMR spectroscopic analysis, and pre-column derivative/chiral HPLC analysis in case of 1 for the absolute configurations. All these compounds were obtained from P. glaucus for the first time. Moreover, the known lignan glycoside, phyllanthusmin C (5) showed in vitro cytotoxicities against HL-60, MCF-7 and SW480 cells with IC50 values of 9.2 +/- 0.2, 19.2 +/- 1.7 and 20.5 +/- 0.9, respectively. |
| 关键词 | Phyllanthus Glaucus Wall. Ex Mull. Arg Glycoside Arylnaphthalene Lignan Phenolics Cytotoxicity |
| DOI | 10.1080/14786419.2015.1023198 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000375841100007 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/26252 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Lanhei Rd 132, Kunming 650201, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yu, Shan,Lv, Jun-Jiang,Zhao, Jian-Qiang,et al. New cytotoxic lignan glycosides from Phyllanthus glaucus[J]. NATURAL PRODUCT RESEARCH,2016,30(4):419-425. |
| APA | Yu, Shan.,Lv, Jun-Jiang.,Zhao, Jian-Qiang.,Li, Yan.,Wang, Dong.,...&Zhang, Ying-Jun.(2016).New cytotoxic lignan glycosides from Phyllanthus glaucus.NATURAL PRODUCT RESEARCH,30(4),419-425. |
| MLA | Yu, Shan,et al."New cytotoxic lignan glycosides from Phyllanthus glaucus".NATURAL PRODUCT RESEARCH 30.4(2016):419-425. |
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