| Cyclotides from Chinese Plants | |
| Tan, Ning-Hua; He, Wen-Jun; Craik, DJ | |
| 2015 | |
| 发表期刊 | PLANT CYCLOTIDES
 |
| 卷号 | 76页码:79-111 |
| 摘要 | Intense global research interest has been directed toward the study of cyclotides in plants. However, it is only in the last decade that Chinese scientists have become involved in this field. Many cyclotide-containing plants are used in traditional Chinese medicines (TCMs), and these plants have therefore become hot resources in the cyclotide area. In this chapter, we systematically describe progress in understanding the chemistry and biology of cyclotides discovered from Chinese plants, including methods of chemical detection, distribution, chemotaxonomy, extraction, isolation, structural elucidation, and biological activity. We focus on our newly developed thin layer chromatography chemical method for the detection of cyclotides, which is a cost-effective alternative to mass spectroscopy. We have also optimized the isolation procedures to develop an approach for the cost-and time-effective extraction of cyclotides from plants. Using these chemical detection and isolation methods, we have characterized new cyclotides in Chinese plants with cytotoxic, hemolytic, and trypsin inhibitory activities. This work expands the number of characterized cyclotides in the plant kingdom and provides interesting results about the active ingredients of TCMs. |
| DOI | 10.1016/bs.abr.2015.09.009 |
| 收录类别 | BSCI ; SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000376190900005 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/26245 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming, Yunnan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Tan, Ning-Hua,He, Wen-Jun,Craik, DJ. Cyclotides from Chinese Plants[J]. PLANT CYCLOTIDES,2015,76:79-111. |
| APA | Tan, Ning-Hua,He, Wen-Jun,&Craik, DJ.(2015).Cyclotides from Chinese Plants.PLANT CYCLOTIDES,76,79-111. |
| MLA | Tan, Ning-Hua,et al."Cyclotides from Chinese Plants".PLANT CYCLOTIDES 76(2015):79-111. |
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| tan2015.pdf（1900KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | 浏览 下载 | |
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