| Two New Cinnamyl Isovalerate Derivatives from Sabina gaussenii | |
| Sun, Zhang-Hua1,2; Tan, Ning-Hua3; Zeng, Guang-Zhi3; Zhang, Yu-Mei1,3 | |
| 2016-05-01 | |
| 发表期刊 | MOLECULES
 |
| 卷号 | 21期号:5 |
| 摘要 | Chemical investigation of the 90% acetone extract of the branches and leaves of Sabina gaussenii led to the isolation of two new cinnamyl isovalerate derivatives (1-2) and eighteen known compounds (3-20). Their structures were determined mainly by means of MS, 1D- and 2D-NMR data, and this is the first time these compounds have been reported from this plant. The biological activity test results indicated that the 90% acetone extract showed cytotoxicity against the human lung adenocarcinoma (A549) cell line (IC50 = 0.98 +/- 0.1 mu g/mL), compound 6 showed cytotoxicities against human cervical carcinoma (HeLa) (IC50 = 0.4 +/- 0.1 mu M) and human gastric carcinoma (BGC-823) (IC50 = 0.9 +/- 0.2 mu M) cancer cell lines, and compound 19 showed cytotoxicities against HeLa (IC50 = 1.5 +/- 0.4 mu M), BGC-823 (IC50 = 7.0 +/- 0.8 mu M), and A549 (IC50 = 10.6 +/- 1.5 mu M) cancer cell lines. |
| 关键词 | Sabina Gaussenii Cinnamyl Isovalerate Cytotoxicity |
| DOI | 10.3390/molecules21050571 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000380241600035 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/26227 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Key Lab Trop Plant Resources & Sustainable Use, Xishuangbanna Trop Bot Garden, Kunming 650223, Peoples R China 2.Guangdong Inst Microbiol, State Key Lab Appl Microbiol Southern China, Guangdong Prov Key Lab Microbial Culture Collect, Guangdong Open Lab Appl Microbiol, Guangzhou 510070, Guangdong, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China |
| 推荐引用方式 GB/T 7714 | Sun, Zhang-Hua,Tan, Ning-Hua,Zeng, Guang-Zhi,et al. Two New Cinnamyl Isovalerate Derivatives from Sabina gaussenii[J]. MOLECULES,2016,21(5). |
| APA | Sun, Zhang-Hua,Tan, Ning-Hua,Zeng, Guang-Zhi,&Zhang, Yu-Mei.(2016).Two New Cinnamyl Isovalerate Derivatives from Sabina gaussenii.MOLECULES,21(5). |
| MLA | Sun, Zhang-Hua,et al."Two New Cinnamyl Isovalerate Derivatives from Sabina gaussenii".MOLECULES 21.5(2016). |
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