| Alkaloids from Veratrum taliense Exert Cardiovascular Toxic Effects via Cardiac Sodium Channel Subtype 1.5 | |
Wang, Gan1,2; Rong, Ming-Qiang2; Li, Qiong3; Liu, Ya-Ping3; Long, Cheng-Bo2; Meng, Ping2; Yao, Hui-Ming1; Lai, Ren1,2; Luo, Xiao-Dong3
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| 2016 | |
| 发表期刊 | TOXINS
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| 卷号 | 8期号:1 |
| 摘要 | Several species of the genus Veratrum that produce steroid alkaloids are commonly used to treat pain and hypertension in China and Europe. However, Veratrum alkaloids (VAs) induce serious cardiovascular toxicity. In China, Veratrum treatment often leads to many side effects and even causes the death of patients, but the pathophysiological mechanisms under these adverse effects are not clear. Here, two solanidine-type VAs (isorubijervine and rubijervine) isolated from Veratrum taliense exhibited strong cardiovascular toxicity. A pathophysiological study indicated that these VAs blocked sodium channels Na(V)1.3-1.5 and exhibited the strongest ability to inhibit Na(V)1.5, which is specifically expressed in cardiac tissue and plays an essential role in cardiac physiological function. This result reveals that VAs exert their cardiovascular toxicity via the Na(V)1.5 channel. The effects of VAs on Na(V)1.3 and Na(V)1.4 may be related to their analgesic effect and skeletal muscle toxicity, respectively. |
| 关键词 | Veratrum Taliense Na(v)1.5 Cardiovascular Toxicity |
| DOI | 10.3390/toxins8010012 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000374332700012 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/26211 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Nanjing Agr Univ, Coll Life Sci, Nanjing 210095, Jiangsu, Peoples R China 2.Chinese Acad Sci & Yunnan Prov, Kunming Inst Zool, Key Lab Anim Models & Human Dis Mech, Kunming 650223, Yunnan, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Gan,Rong, Ming-Qiang,Li, Qiong,et al. Alkaloids from Veratrum taliense Exert Cardiovascular Toxic Effects via Cardiac Sodium Channel Subtype 1.5[J]. TOXINS,2016,8(1). |
| APA | Wang, Gan.,Rong, Ming-Qiang.,Li, Qiong.,Liu, Ya-Ping.,Long, Cheng-Bo.,...&Luo, Xiao-Dong.(2016).Alkaloids from Veratrum taliense Exert Cardiovascular Toxic Effects via Cardiac Sodium Channel Subtype 1.5.TOXINS,8(1). |
| MLA | Wang, Gan,et al."Alkaloids from Veratrum taliense Exert Cardiovascular Toxic Effects via Cardiac Sodium Channel Subtype 1.5".TOXINS 8.1(2016). |
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