| Central anti-fatigue activity of verbascoside | |
| Zhu, Meiju1; Zhu, Hongzhu1; Tan, Ninghua2; Wang, Hui1; Chu, Hongbiao1; Zhang, Chonglin1 | |
| 2016-03-11 | |
| 发表期刊 | NEUROSCIENCE LETTERS
 |
| 卷号 | 616页码:75-79 |
| 摘要 | In this study, the effects of verbascoside on treadmill exercise endurance, 5-hydroxytryptamine (5- HT) concentrations, the second isoforms of tryptophan hydroxylase (TPH2) and serotonergic type 1B inhibitory autoreceptors (5-HT1B) protein expression in the caudate putamen of exercised rats were investigated. Sixty Sprague-Dawley male rats were randomly divided into six groups: normal group, exercise group, exercise and verbascoside (0.1 mg/kg) treated group, exercise and verbascoside (1 mg/kg) treated group, exercise and verbascoside (10 mg/kg) treated group, exercise and caffeine (10 mg/kg) treated group. In exercise groups, rats were put on treadmill and forced to run for 30 min once a day for 6 consecutive days. On the 7th day of the experiment, the time to exhaustion in treadmill exercise was determined for the trained groups. Immediately after the determination of the exhaustion time, all rats were sacrificed. 5-HT concentrations were detected by HPLC analysis. TPH2 and 5-HT1B protein expression were measured by western blot analysis. We found that verbascoside could prolong the time to exhaustion in treadmill exercise and suppress the exercise-induced increase of 5-HT synthesis and TPH2 protein expression, and prevent the exercise-induced decrease of 5-HT1B protein expression in the caudate putamen. Verbascoside was found as effective as caffeine in these effects. Verbascoside at 10 mg/kg improved endurance of exercised rats. |
| 关键词 | Pedicularis Species Neurotransmitter Exercise |
| DOI | 10.1016/j.neulet.2016.01.042 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000373553900013 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/26207 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Jinggangshan Univ, Sch Sports Sci, Jian 343009, Jiangxi, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhu, Meiju,Zhu, Hongzhu,Tan, Ninghua,et al. Central anti-fatigue activity of verbascoside[J]. NEUROSCIENCE LETTERS,2016,616:75-79. |
| APA | Zhu, Meiju,Zhu, Hongzhu,Tan, Ninghua,Wang, Hui,Chu, Hongbiao,&Zhang, Chonglin.(2016).Central anti-fatigue activity of verbascoside.NEUROSCIENCE LETTERS,616,75-79. |
| MLA | Zhu, Meiju,et al."Central anti-fatigue activity of verbascoside".NEUROSCIENCE LETTERS 616(2016):75-79. |
| 条目包含的文件 | ||||||
| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
| zhu20116.pdf（1234KB） | 开放获取 | CC BY-NC-SA | 浏览 请求全文 | |||
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。
修改评论