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题名: Iridium-Catalyzed Enantioselective Indole Cyclization: Application to the Total Synthesis and Absolute Stereochemical Assignment of (-)-AspidophyllineA
作者: Jiang, Shi-Zhi1; Zeng, Xue-Yi1, 2; Liang, Xiao1, 2; Lei, Ting1; Wei, Kun1; null(杨玉荣)1
刊名: ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
关键词: cyclizations ; enantioselectivity ; indoles ; iridium ; total synthesis
英文摘要: The first enantioselective total synthesis of (-)-aspidophyllineA, including assignment of its absolute configuration has been accomplished. A key element of the synthesis is a highly enantioselective indole allylic alkylation/iminium cyclization cascade which was developed by employing a combination of Lewis acid activation and an iridium/ligand catalyst. This strategy relies on the direct use of 2,3-disubstituted indoles with secondary allylic alcohols appended at C2 and heteronucleophiles appended at C3, indoles which are easily prepared from simple starting materials under C-H activation conditions.
出版日期: 2016-03-14
卷号: 55, 期号:12, 页码:4044-4048
DOI标识: 10.1002/anie.201511549
语种: 英语
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内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/26181
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Lanhei 132, Kunming 650201, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100039, Peoples R China
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