Iridium-Catalyzed Enantioselective Indole Cyclization: Application to the Total Synthesis and Absolute Stereochemical Assignment of (-)-AspidophyllineA

doi:10.1002/anie.201511549

	Iridium-Catalyzed Enantioselective Indole Cyclization: Application to the Total Synthesis and Absolute Stereochemical Assignment of (-)-AspidophyllineA
	Jiang, Shi-Zhi 1; Zeng, Xue-Yi 1,2; Liang, Xiao 1,2; Lei, Ting1 ; Wei, Kun 1; Yang, Yu-Rong1
	2016-03-14
发表期刊	ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷号	55 期号:12 页码:4044-4048
摘要	The first enantioselective total synthesis of (-)-aspidophyllineA, including assignment of its absolute configuration has been accomplished. A key element of the synthesis is a highly enantioselective indole allylic alkylation/iminium cyclization cascade which was developed by employing a combination of Lewis acid activation and an iridium/ligand catalyst. This strategy relies on the direct use of 2,3-disubstituted indoles with secondary allylic alcohols appended at C2 and heteronucleophiles appended at C3, indoles which are easily prepared from simple starting materials under C-H activation conditions.
关键词	Cyclizations Enantioselectivity Indoles Iridium Total Synthesis
DOI	10.1002/anie.201511549
收录类别	SCI ; IC ; CCR
语种	英语
WOS记录号	WOS:000372660400033
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/26181
专题	植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Lanhei 132, Kunming 650201, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100039, Peoples R China
推荐引用方式 GB/T 7714	Jiang, Shi-Zhi,Zeng, Xue-Yi,Liang, Xiao,et al. Iridium-Catalyzed Enantioselective Indole Cyclization: Application to the Total Synthesis and Absolute Stereochemical Assignment of (-)-AspidophyllineA[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2016,55(12):4044-4048.
APA	Jiang, Shi-Zhi,Zeng, Xue-Yi,Liang, Xiao,Lei, Ting,Wei, Kun,&Yang, Yu-Rong.(2016).Iridium-Catalyzed Enantioselective Indole Cyclization: Application to the Total Synthesis and Absolute Stereochemical Assignment of (-)-AspidophyllineA.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,55(12),4044-4048.
MLA	Jiang, Shi-Zhi,et al."Iridium-Catalyzed Enantioselective Indole Cyclization: Application to the Total Synthesis and Absolute Stereochemical Assignment of (-)-AspidophyllineA".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 55.12(2016):4044-4048.

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