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题名: Chemical Constituents of Excoecaria acerifolia and Their Bioactivities
作者: Zhao, Yan-Li1, 2; He, Qiu-Xia3; Li, Yang1; Wang, Si-Feng3; Liu, Ke-Chun3; Yang Yongping(杨永平)1, 4; Li, Xiao-Li1, 4
刊名: MOLECULES
关键词: kaurane diterpenoid ; Excoecaria acerifolia ; NMR ; antiangiogenic ; antiproliferative
中文摘要: A new kaurane diterpenoid, 3 alpha, 18-dihydroxy-3 beta,20-epoxykaur-15-ene (1), was isolated from the aerial parts of Excoecaria acerifolia (Euphorbiaceae) together with 16 known compounds. Their structures were identified by extensive spectral analysis, especially 2D NMR techniques. Antiangiogenic effects of compounds 1-6 and 9-17 were evaluated using a zebrafish model, with compound 9 being active in this bioassay. At the same time, compounds 4, 6, 10, 11 showed activity in inhibiting the growth of A549 lung cancer cells, and the compound 10 also showed apoptosis-inducing effects on A549 lung cancer cells.
出版日期: 2010-04-01
卷号: 15, 期号:4, 页码:2178-2186
语种: 英语
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内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/2617
Appears in Collections:中国科学院青藏高原研究所昆明部_期刊论文

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作者单位: 1.Chinese Acad Sci, Kunming Inst Bot, Lab Ethnobot, Kunming 650204, Yunnan, Peoples R China
2.Chinese Acad Sci, Grad Univ, Beijing 100039, Peoples R China
3.Shandong Acad Sci, Inst Biol, Jinan 250014, Shandong, Peoples R China
4.Chinese Acad Sci, Inst Tibetan Plateau Res Kunming, Kunming Inst Bot, Kunming 650204, Yunnan, Peoples R China

Recommended Citation:
Zhao, YL; He, QX; Li, Y; Wang, SF; Liu, KC; Yang, YP; Li, XL.Chemical Constituents of Excoecaria acerifolia and Their Bioactivities,MOLECULES,2010,15(4):2178-2186
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