Chemical Constituents of Excoecaria acerifolia and Their Bioactivities

doi:10.3390/molecules15042178

	Chemical Constituents of Excoecaria acerifolia and Their Bioactivities
	Zhao, Yan-Li 1,2; He, Qiu-Xia 3; Li, Yang 1; Wang, Si-Feng 3; Liu, Ke-Chun 3; Yang, Yong-Ping1,4 ; Li, Xiao-Li 1,4
	2010-04-01
发表期刊	MOLECULES
ISSN	1420-3049
卷号	15 期号:4 页码:2178-2186
摘要	A new kaurane diterpenoid, 3 alpha, 18-dihydroxy-3 beta,20-epoxykaur-15-ene (1), was isolated from the aerial parts of Excoecaria acerifolia (Euphorbiaceae) together with 16 known compounds. Their structures were identified by extensive spectral analysis, especially 2D NMR techniques. Antiangiogenic effects of compounds 1-6 and 9-17 were evaluated using a zebrafish model, with compound 9 being active in this bioassay. At the same time, compounds 4, 6, 10, 11 showed activity in inhibiting the growth of A549 lung cancer cells, and the compound 10 also showed apoptosis-inducing effects on A549 lung cancer cells.; A new kaurane diterpenoid, 3 alpha, 18-dihydroxy-3 beta,20-epoxykaur-15-ene (1), was isolated from the aerial parts of Excoecaria acerifolia (Euphorbiaceae) together with 16 known compounds. Their structures were identified by extensive spectral analysis, especially 2D NMR techniques. Antiangiogenic effects of compounds 1-6 and 9-17 were evaluated using a zebrafish model, with compound 9 being active in this bioassay. At the same time, compounds 4, 6, 10, 11 showed activity in inhibiting the growth of A549 lung cancer cells, and the compound 10 also showed apoptosis-inducing effects on A549 lung cancer cells.
关键词	Kaurane Diterpenoid Excoecaria Acerifolia Nmr Antiangiogenic Antiproliferative
学科领域	Chemistry, Organic
DOI	10.3390/molecules15042178
收录类别	SCI
语种	英语
WOS记录号	WOS:000277147400012
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/2617
专题	中国科学院青藏高原研究所昆明部
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, Lab Ethnobot, Kunming 650204, Yunnan, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100039, Peoples R China 3.Shandong Acad Sci, Inst Biol, Jinan 250014, Shandong, Peoples R China 4.Chinese Acad Sci, Inst Tibetan Plateau Res Kunming, Kunming Inst Bot, Kunming 650204, Yunnan, Peoples R China
推荐引用方式 GB/T 7714	Zhao, Yan-Li,He, Qiu-Xia,Li, Yang,et al. Chemical Constituents of Excoecaria acerifolia and Their Bioactivities[J]. MOLECULES,2010,15(4):2178-2186.
APA	Zhao, Yan-Li.,He, Qiu-Xia.,Li, Yang.,Wang, Si-Feng.,Liu, Ke-Chun.,...&Li, Xiao-Li.(2010).Chemical Constituents of Excoecaria acerifolia and Their Bioactivities.MOLECULES,15(4),2178-2186.
MLA	Zhao, Yan-Li,et al."Chemical Constituents of Excoecaria acerifolia and Their Bioactivities".MOLECULES 15.4(2010):2178-2186.

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