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Chemical Constituents of Excoecaria acerifolia and Their Bioactivities
Zhao, Yan-Li1,2; He, Qiu-Xia3; Li, Yang1; Wang, Si-Feng3; Liu, Ke-Chun3; Yang, Yong-Ping1,4; Li, Xiao-Li1,4
2010-04-01
发表期刊MOLECULES
ISSN1420-3049
卷号15期号:4页码:2178-2186
摘要A new kaurane diterpenoid, 3 alpha, 18-dihydroxy-3 beta,20-epoxykaur-15-ene (1), was isolated from the aerial parts of Excoecaria acerifolia (Euphorbiaceae) together with 16 known compounds. Their structures were identified by extensive spectral analysis, especially 2D NMR techniques. Antiangiogenic effects of compounds 1-6 and 9-17 were evaluated using a zebrafish model, with compound 9 being active in this bioassay. At the same time, compounds 4, 6, 10, 11 showed activity in inhibiting the growth of A549 lung cancer cells, and the compound 10 also showed apoptosis-inducing effects on A549 lung cancer cells.; A new kaurane diterpenoid, 3 alpha, 18-dihydroxy-3 beta,20-epoxykaur-15-ene (1), was isolated from the aerial parts of Excoecaria acerifolia (Euphorbiaceae) together with 16 known compounds. Their structures were identified by extensive spectral analysis, especially 2D NMR techniques. Antiangiogenic effects of compounds 1-6 and 9-17 were evaluated using a zebrafish model, with compound 9 being active in this bioassay. At the same time, compounds 4, 6, 10, 11 showed activity in inhibiting the growth of A549 lung cancer cells, and the compound 10 also showed apoptosis-inducing effects on A549 lung cancer cells.
关键词Kaurane Diterpenoid Excoecaria Acerifolia Nmr Antiangiogenic Antiproliferative
资助信息West Light Foundation of the Chinese Academy of Sciences ; MOST [2008BAD98B06]; MAPPA/ICIMOD ; Ford Foundation [1075-0729, 1090-0448]
学科领域Chemistry, Organic
DOI10.3390/molecules15042178
收录类别SCI
语种英语
WOS研究方向Chemistry
WOS类目Chemistry, Organic
WOS记录号WOS:000277147400012
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/2617
专题中国科学院青藏高原研究所昆明部
作者单位1.Chinese Acad Sci, Kunming Inst Bot, Lab Ethnobot, Kunming 650204, Yunnan, Peoples R China
2.Chinese Acad Sci, Grad Univ, Beijing 100039, Peoples R China
3.Shandong Acad Sci, Inst Biol, Jinan 250014, Shandong, Peoples R China
4.Chinese Acad Sci, Inst Tibetan Plateau Res Kunming, Kunming Inst Bot, Kunming 650204, Yunnan, Peoples R China
推荐引用方式
GB/T 7714
Zhao, Yan-Li,He, Qiu-Xia,Li, Yang,et al. Chemical Constituents of Excoecaria acerifolia and Their Bioactivities[J]. MOLECULES,2010,15(4):2178-2186.
APA Zhao, Yan-Li.,He, Qiu-Xia.,Li, Yang.,Wang, Si-Feng.,Liu, Ke-Chun.,...&Li, Xiao-Li.(2010).Chemical Constituents of Excoecaria acerifolia and Their Bioactivities.MOLECULES,15(4),2178-2186.
MLA Zhao, Yan-Li,et al."Chemical Constituents of Excoecaria acerifolia and Their Bioactivities".MOLECULES 15.4(2010):2178-2186.
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