Isolation of Chemical Constituents from the Aerial Parts of Verbascum thapsus and Their Antiangiogenic and Antiproliferative Activities

doi:10.1007/s12272-011-0501-9

	Isolation of Chemical Constituents from the Aerial Parts of Verbascum thapsus and Their Antiangiogenic and Antiproliferative Activities
	Zhao, Yan-Li 2,4; Wang, Si-Feng 3; Li, Yang 2; He, Qiu-Xia 3; Liu, Ke-Chun 3; Yang, Yong-Ping1,2 ; Li, Xiao-Li 2
	2011-05-01
发表期刊	ARCHIVES OF PHARMACAL RESEARCH
ISSN	0253-6269
卷号	34 期号:5 页码:703-707
摘要	Phytochemical investigation of Verbascum thapsus led to the isolation and identification of one new iridoid compound named verbathasin A, along with ten known compounds. The structure and relative stereochemistry of verbathasin A were elucidated by analysis of spectroscopic data. All the isolates except 10-deoxyeucommiol and ajugol were tested for antiangiogenic and antiproliferative activities, and compounds luteolin and 3-O-fucopyranosylsaikogenin F showed promising antiproliferative activities, with an obvious effect of inducing apoptosis of A549 lung cancer cells.; Phytochemical investigation of Verbascum thapsus led to the isolation and identification of one new iridoid compound named verbathasin A, along with ten known compounds. The structure and relative stereochemistry of verbathasin A were elucidated by analysis of spectroscopic data. All the isolates except 10-deoxyeucommiol and ajugol were tested for antiangiogenic and antiproliferative activities, and compounds luteolin and 3-O-fucopyranosylsaikogenin F showed promising antiproliferative activities, with an obvious effect of inducing apoptosis of A549 lung cancer cells.
关键词	Verbascum Thapsus Iridoid Nmr Antiangiogenic Activities Antiproliferative Activities A549
学科领域	Chemistry, Medicinal ; Pharmacology & Pharmacy
DOI	10.1007/s12272-011-0501-9
收录类别	SCI
语种	英语
WOS记录号	WOS:000291365900003
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/2609
专题	中国科学院青藏高原研究所昆明部
作者单位	1.Chinese Acad Sci, Lab Ethnobot, Kunming Inst Bot, Inst Tibetan Plateau Res Kunming, Kunming 650204, Yunnan, Peoples R China 2.Chinese Acad Sci, Key Lab Econ Plants & Biotechnol, Kunming Inst Bot, Kunming 650204, Yunnan, Peoples R China 3.Shandong Acad Sci, Inst Biol, Jinan 250014, Shandong, Peoples R China 4.Chinese Acad Sci, Grad Univ, Beijing 100039, Peoples R China
推荐引用方式 GB/T 7714	Zhao, Yan-Li,Wang, Si-Feng,Li, Yang,et al. Isolation of Chemical Constituents from the Aerial Parts of Verbascum thapsus and Their Antiangiogenic and Antiproliferative Activities[J]. ARCHIVES OF PHARMACAL RESEARCH,2011,34(5):703-707.
APA	Zhao, Yan-Li.,Wang, Si-Feng.,Li, Yang.,He, Qiu-Xia.,Liu, Ke-Chun.,...&Li, Xiao-Li.(2011).Isolation of Chemical Constituents from the Aerial Parts of Verbascum thapsus and Their Antiangiogenic and Antiproliferative Activities.ARCHIVES OF PHARMACAL RESEARCH,34(5),703-707.
MLA	Zhao, Yan-Li,et al."Isolation of Chemical Constituents from the Aerial Parts of Verbascum thapsus and Their Antiangiogenic and Antiproliferative Activities".ARCHIVES OF PHARMACAL RESEARCH 34.5(2011):703-707.

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