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Isolation of Chemical Constituents from the Aerial Parts of Verbascum thapsus and Their Antiangiogenic and Antiproliferative Activities
Zhao, Yan-Li2,4; Wang, Si-Feng3; Li, Yang2; He, Qiu-Xia3; Liu, Ke-Chun3; Yang, Yong-Ping1,2; Li, Xiao-Li2
2011-05-01
发表期刊ARCHIVES OF PHARMACAL RESEARCH
ISSN0253-6269
卷号34期号:5页码:703-707
摘要Phytochemical investigation of Verbascum thapsus led to the isolation and identification of one new iridoid compound named verbathasin A, along with ten known compounds. The structure and relative stereochemistry of verbathasin A were elucidated by analysis of spectroscopic data. All the isolates except 10-deoxyeucommiol and ajugol were tested for antiangiogenic and antiproliferative activities, and compounds luteolin and 3-O-fucopyranosylsaikogenin F showed promising antiproliferative activities, with an obvious effect of inducing apoptosis of A549 lung cancer cells.; Phytochemical investigation of Verbascum thapsus led to the isolation and identification of one new iridoid compound named verbathasin A, along with ten known compounds. The structure and relative stereochemistry of verbathasin A were elucidated by analysis of spectroscopic data. All the isolates except 10-deoxyeucommiol and ajugol were tested for antiangiogenic and antiproliferative activities, and compounds luteolin and 3-O-fucopyranosylsaikogenin F showed promising antiproliferative activities, with an obvious effect of inducing apoptosis of A549 lung cancer cells.
关键词Verbascum Thapsus Iridoid Nmr Antiangiogenic Activities Antiproliferative Activities A549
资助信息West Light Foundation of the Chinese Academy of Sciences ; MOST [2008BAD98B06]; MAPs Traditional Knowledge Network in Southwest China from MAPPA/ICIMOD ; Ford Foundation [1075-0729, 1090-0448]
学科领域Chemistry, Medicinal ; Pharmacology & Pharmacy
DOI10.1007/s12272-011-0501-9
收录类别SCI
语种英语
WOS研究方向Pharmacology & Pharmacy
WOS类目Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS记录号WOS:000291365900003
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/2609
专题中国科学院青藏高原研究所昆明部
作者单位1.Chinese Acad Sci, Lab Ethnobot, Kunming Inst Bot, Inst Tibetan Plateau Res Kunming, Kunming 650204, Yunnan, Peoples R China
2.Chinese Acad Sci, Key Lab Econ Plants & Biotechnol, Kunming Inst Bot, Kunming 650204, Yunnan, Peoples R China
3.Shandong Acad Sci, Inst Biol, Jinan 250014, Shandong, Peoples R China
4.Chinese Acad Sci, Grad Univ, Beijing 100039, Peoples R China
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Zhao, Yan-Li,Wang, Si-Feng,Li, Yang,et al. Isolation of Chemical Constituents from the Aerial Parts of Verbascum thapsus and Their Antiangiogenic and Antiproliferative Activities[J]. ARCHIVES OF PHARMACAL RESEARCH,2011,34(5):703-707.
APA Zhao, Yan-Li.,Wang, Si-Feng.,Li, Yang.,He, Qiu-Xia.,Liu, Ke-Chun.,...&Li, Xiao-Li.(2011).Isolation of Chemical Constituents from the Aerial Parts of Verbascum thapsus and Their Antiangiogenic and Antiproliferative Activities.ARCHIVES OF PHARMACAL RESEARCH,34(5),703-707.
MLA Zhao, Yan-Li,et al."Isolation of Chemical Constituents from the Aerial Parts of Verbascum thapsus and Their Antiangiogenic and Antiproliferative Activities".ARCHIVES OF PHARMACAL RESEARCH 34.5(2011):703-707.
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