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题名: Isolation of Chemical Constituents from the Aerial Parts of Verbascum thapsus and Their Antiangiogenic and Antiproliferative Activities
作者: Zhao, Yan-Li2, 4; Wang, Si-Feng3; Li, Yang2; He, Qiu-Xia3; Liu, Ke-Chun3; Yang Yongping(杨永平)1, 2; Li, Xiao-Li2
刊名: ARCHIVES OF PHARMACAL RESEARCH
关键词: Verbascum thapsus ; Iridoid ; NMR ; Antiangiogenic activities ; Antiproliferative activities ; A549
中文摘要: Phytochemical investigation of Verbascum thapsus led to the isolation and identification of one new iridoid compound named verbathasin A, along with ten known compounds. The structure and relative stereochemistry of verbathasin A were elucidated by analysis of spectroscopic data. All the isolates except 10-deoxyeucommiol and ajugol were tested for antiangiogenic and antiproliferative activities, and compounds luteolin and 3-O-fucopyranosylsaikogenin F showed promising antiproliferative activities, with an obvious effect of inducing apoptosis of A549 lung cancer cells.
出版日期: 2011-05-01
卷号: 34, 期号:5, 页码:703-707
语种: 英语
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内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/2609
Appears in Collections:中国科学院青藏高原研究所昆明部_期刊论文

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作者单位: 1.Chinese Acad Sci, Lab Ethnobot, Kunming Inst Bot, Inst Tibetan Plateau Res Kunming, Kunming 650204, Yunnan, Peoples R China
2.Chinese Acad Sci, Key Lab Econ Plants & Biotechnol, Kunming Inst Bot, Kunming 650204, Yunnan, Peoples R China
3.Shandong Acad Sci, Inst Biol, Jinan 250014, Shandong, Peoples R China
4.Chinese Acad Sci, Grad Univ, Beijing 100039, Peoples R China

Recommended Citation:
Zhao, YL; Wang, SF; Li, Y; He, QX; Liu, KC; Yang, YP; Li, XL.Isolation of Chemical Constituents from the Aerial Parts of Verbascum thapsus and Their Antiangiogenic and Antiproliferative Activities,ARCHIVES OF PHARMACAL RESEARCH,2011,34(5):703-707
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