Stereoselective Synthesis of Diazabicyclic beta-Lactams through Intramolecular Amination of Unactivated C(sp(3))-H Bonds of Carboxamides by Palladium Catalysis
Zhang, Shi-Jin1,2; Sun, Wen-Wu2,3; Cao, Pei2; Dong, Xiao-Ping1; Liu, Ji-Kai4; Wu, Bin2,4
2016-02-05
发表期刊JOURNAL OF ORGANIC CHEMISTRY
卷号81期号:3页码:956-968
摘要An efficient C(sp(3))-H bond activation and intramolecular amination reaction via palladium catalysis at the beta-position of carboxyamides to make beta-lactams was described. The investigation of the substrate scope showed that the current reaction conditions favored activation of the beta-methylene group. Short sequences were developed for preparation of various diazabicyclic beta-lactarn compounds with this method as the key step from chiral proline and piperidine derivatives.
资助信息"Hundred Talents Project" of Chinese Academy of Science; "High-end Science and Technology Talents Program" of Yunnan Province(2011HA008); National Natural Science Foundation of China(21472198); Yunnan Province of China(2014FA039)
DOI10.1021/acs.joc.5b02532
收录类别SCI ; IC ; CCR
语种英语
WOS研究方向Chemistry
WOS类目Chemistry, Organic
WOS记录号WOS:000369771600022
引用统计
被引频次:16[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/25957
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chengdu Univ Tradit Chinese Med, Coll Pharm, Chengdu 611137, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
4.South Cent Univ Nationalities, Sch Pharmaceut Sci, Wuhan 430074, Peoples R China
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Zhang, Shi-Jin,Sun, Wen-Wu,Cao, Pei,et al. Stereoselective Synthesis of Diazabicyclic beta-Lactams through Intramolecular Amination of Unactivated C(sp(3))-H Bonds of Carboxamides by Palladium Catalysis[J]. JOURNAL OF ORGANIC CHEMISTRY,2016,81(3):956-968.
APA Zhang, Shi-Jin,Sun, Wen-Wu,Cao, Pei,Dong, Xiao-Ping,Liu, Ji-Kai,&Wu, Bin.(2016).Stereoselective Synthesis of Diazabicyclic beta-Lactams through Intramolecular Amination of Unactivated C(sp(3))-H Bonds of Carboxamides by Palladium Catalysis.JOURNAL OF ORGANIC CHEMISTRY,81(3),956-968.
MLA Zhang, Shi-Jin,et al."Stereoselective Synthesis of Diazabicyclic beta-Lactams through Intramolecular Amination of Unactivated C(sp(3))-H Bonds of Carboxamides by Palladium Catalysis".JOURNAL OF ORGANIC CHEMISTRY 81.3(2016):956-968.
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