Stereoselective Synthesis of Diazabicyclic beta-Lactams through Intramolecular Amination of Unactivated C(sp(3))-H Bonds of Carboxamides by Palladium Catalysis
Zhang, Shi-Jin1,2; Sun, Wen-Wu2,3; Cao, Pei2; Dong, Xiao-Ping1; Liu, Ji-Kai4; Wu, Bin2,4
2016-02-05
Source PublicationJOURNAL OF ORGANIC CHEMISTRY
Volume81Issue:3Pages:956-968
AbstractAn efficient C(sp(3))-H bond activation and intramolecular amination reaction via palladium catalysis at the beta-position of carboxyamides to make beta-lactams was described. The investigation of the substrate scope showed that the current reaction conditions favored activation of the beta-methylene group. Short sequences were developed for preparation of various diazabicyclic beta-lactarn compounds with this method as the key step from chiral proline and piperidine derivatives.
DOI10.1021/acs.joc.5b02532
Indexed BySCI ; IC ; CCR
Language英语
WOS Research AreaChemistry
WOS SubjectChemistry, Organic
WOS IDWOS:000369771600022
Citation statistics
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/25957
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Chengdu Univ Tradit Chinese Med, Coll Pharm, Chengdu 611137, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
4.South Cent Univ Nationalities, Sch Pharmaceut Sci, Wuhan 430074, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Shi-Jin,Sun, Wen-Wu,Cao, Pei,et al. Stereoselective Synthesis of Diazabicyclic beta-Lactams through Intramolecular Amination of Unactivated C(sp(3))-H Bonds of Carboxamides by Palladium Catalysis[J]. JOURNAL OF ORGANIC CHEMISTRY,2016,81(3):956-968.
APA Zhang, Shi-Jin,Sun, Wen-Wu,Cao, Pei,Dong, Xiao-Ping,Liu, Ji-Kai,&Wu, Bin.(2016).Stereoselective Synthesis of Diazabicyclic beta-Lactams through Intramolecular Amination of Unactivated C(sp(3))-H Bonds of Carboxamides by Palladium Catalysis.JOURNAL OF ORGANIC CHEMISTRY,81(3),956-968.
MLA Zhang, Shi-Jin,et al."Stereoselective Synthesis of Diazabicyclic beta-Lactams through Intramolecular Amination of Unactivated C(sp(3))-H Bonds of Carboxamides by Palladium Catalysis".JOURNAL OF ORGANIC CHEMISTRY 81.3(2016):956-968.
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