中国科学院昆明植物研究所机构知识库
Advanced  
KIB OpenIR  > 植物化学与西部植物资源持续利用国家重点实验室  > 期刊论文
题名: Structural characterization and immunomodulating activity of polysaccharide from Dendrobium officinale
作者: He, Tao-Bin1, 2, 3; Huang, Yan-Ping1, 3; Yang, Liu2; Liu, Ti-Ti1, 3; Gong, Wan-Ying1, 3; Wang, Xuan-Jun1, 3; Sheng, Jun1, 3; Hu, Jiang-Miao2
刊名: INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
关键词: Dendrobium officinale ; Polysaccharide ; Immunomodulation
英文摘要: A neutral heteropolysaccharide (DOP-1-1) consisted by mannose and glucose (5.9:1) with an average molecular weight at about 1.78 x 10(5) Da was purified from Dendrobium officinale. Based on Fourier transform infrared spectrum (FT-IR) and nuclear magnetic resonance (NMR) spectra, it suggested that partial structure of DOP-1-1 is an O-acetylated glucomannan with beta-D configuration in pyranose sugar forms. The immunomodulatory activity of DOP-1-1 was evaluated by secretion level of cytokine (interleukin (IL)-1 beta and IL-10) and tumor necrosis factor (TNF)-alpha; in vitro. Our results suggested that DOP-1-1 could stimulate cytokine production (TNF-alpha, IL-1 beta) in cells. These findings demonstrated that the purified polysaccharide from D. officinale presented significant immune-modulating activities. Furthermore, by Western-blot we can found that the signaling pathways of DOP-1-1 induced immune activities involving ERK1/2 and NF-kappa B. As to antioxidant activity, DOP-1-1 hadn't showed remarkable scavenging capacity of 1,1-diphenyl-2-picrylhydrazyl radical (DPPH) in contrast with other studies of polysaccharides from D. officinale. (C) 2015 Elsevier B.V. All rights reserved.
出版日期: 2016-02-01
卷号: 83, 页码:34-41
DOI标识: 10.1016/j.ijbiomac.2015.11.038
语种: 英语
收录类别: SCI
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/25947
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

Files in This Item: Download All
File Name/ File Size Content Type Version Access License
he2016.pdf(1773KB)----开放获取View Download

作者单位: 1.Yunna Agr Univ, Coll Food Sci & Technol, Kunming 650201, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, Kunming 650201, Peoples R China
3.Yunnan Agr Univ, Minist Educ, Key Lab Pu Er Tea Sci, Kunming 650201, Peoples R China
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[He, Tao-Bin]'s Articles
[Huang, Yan-Ping]'s Articles
[Yang, Liu]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[He, Tao-Bin]‘s Articles
[Huang, Yan-Ping]‘s Articles
[Yang, Liu]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
文件名: he2016.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  中国科学院昆明植物研究所 - Feedback
Powered by CSpace