| Cytotoxic flavonoids from the young twigs and leaves of Caesalpinia bonduc (Linn) Roxb | |
| Ogunlana, Olubanke Olujoke1; He, Wen Jun2; Fan, Jun Ting2; Zeng, Guang Zhi2; Ji, Chang Jiu2; Zheng, Yu Quing2; Olagunju, Joseph Abayomi3; Akindahunsi, Afolabi Akintunde4; Tan, Ning Hua2 | |
| 2015-11-01 | |
| 发表期刊 | PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES
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| 卷号 | 28期号:6页码:2191-2198 |
| 摘要 | The extraction, fractionation and recognition of flavonoids from the ethanolic extract of young twigs and leaves of C. bonduc were carried out. In addition, cytotoxic study of the flavonoids on two cancer cell lines, BGC-823 and HeLa was carried our using sulphorhodamine B assay. Seven flavonoids, six of which are being reported for the first time in this plant, were isolated. Their structures were identified by MS and NMR spectroscopic methods. Petroleum ether, ethyl acetate and water fractions exhibited moderate cytotoxic activity against HeLa cells. Five compounds showed cytotoxic activity against HeLa cell in comparison with Paclitaxel, while only one compound showed a good degree of cytotoxic activity against BGC-823 cell in comparison to Paclitaxel. The results obtained showed a structure activity relationship. |
| 关键词 | Caesalpinia Bonduc Flavonoids Cytotoxic Activity |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000366881700040 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/25329 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Covenant Univ, Dept Biol Sci, Coll Sci & Technol, Ota, Ogun State, Nigeria 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming, Yunnan, Peoples R China 3.Lagos State Univ, Dept Med Biochem, Coll Med, Fac Basic Med Sci, Ikeja, Lagos State, Nigeria 4.Fed Univ Technol Akure, Dept Biochem, Akure, Nigeria |
| 推荐引用方式 GB/T 7714 | Ogunlana, Olubanke Olujoke,He, Wen Jun,Fan, Jun Ting,et al. Cytotoxic flavonoids from the young twigs and leaves of Caesalpinia bonduc (Linn) Roxb[J]. PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES,2015,28(6):2191-2198. |
| APA | Ogunlana, Olubanke Olujoke.,He, Wen Jun.,Fan, Jun Ting.,Zeng, Guang Zhi.,Ji, Chang Jiu.,...&Tan, Ning Hua.(2015).Cytotoxic flavonoids from the young twigs and leaves of Caesalpinia bonduc (Linn) Roxb.PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES,28(6),2191-2198. |
| MLA | Ogunlana, Olubanke Olujoke,et al."Cytotoxic flavonoids from the young twigs and leaves of Caesalpinia bonduc (Linn) Roxb".PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES 28.6(2015):2191-2198. |
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| Paper-40.pdf（1152KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | 浏览 下载 | |
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