RA-XII inhibits tumour growth and metastasis in breast tumour-bearing mice via reducing cell adhesion and invasion and promoting matrix degradation

doi:10.1038/srep16985

	RA-XII inhibits tumour growth and metastasis in breast tumour-bearing mice via reducing cell adhesion and invasion and promoting matrix degradation
	Leung,Hoi-Wing; Zhao,Si-Meng; Yue,Grace Gar-Lee; Lee,Julia Kin-Ming; Fung,Kwok-Pui; Leung,Ping-Chung; Tan,Ning-Hua; Lau,Clara Bik-San
	2015-11-23
发表期刊	SCIENTIFIC REPORTS
卷号	5
摘要	Cancer cells acquire invasive ability to degrade and adhere to extracellular matrix (ECM) and migrate to adjacent tissues. This ultimately results metastasis. Hence, the present study investigated the in vitro effects of cyclopeptide glycoside, RA-XII on cell adhesion, invasion, proliferation and matrix degradation, and its underlying mechanism in murine breast tumour cells, 4T1. The effect of RA-XII on tumour growth and metastasis in 4T1-bearing mice was also investigated. Our results showed that RA-XII inhibited tumour cell adhesion to collagen, fibronectin and laminin, RA-XII also reduced the expressions of vascular cell adhesion molecule, intracellular adhesion molecule and integrins, and integrin binding. In addition, RA-XII significantly inhibited breast tumour cell migration via interfering cofilin signaling and chemokine receptors. The activities of matrix metalloproteinase-9 and urokinase-type of plasminogen activator, and the expressions of ECM-associated proteinases were attenuated significantly by RA-XII. Furthermore, RA-XII induced G1 phase arrest and inhibited the expressions of cyclins and cyclin-dependent kinases. RA-XII inhibited the expressions of molecules in PI3K/AKT, NF-kappaB, FAK/pSRC, MAPK and EGFR signaling. RA-XII was also shown to have anti-tumour, anti-angiogenic and anti-metastatic activities in metastatic breast tumour-bearing mice. These findings strongly suggested that RA-XII is a potential anti-metastatic agent for breast cancer.
DOI	10.1038/srep16985
收录类别	SCI
语种	英语
WOS记录号	WOS:000365239400003
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/25252
专题	植物化学与西部植物资源持续利用国家重点实验室
推荐引用方式 GB/T 7714	Leung,Hoi-Wing,Zhao,Si-Meng,Yue,Grace Gar-Lee,et al. RA-XII inhibits tumour growth and metastasis in breast tumour-bearing mice via reducing cell adhesion and invasion and promoting matrix degradation[J]. SCIENTIFIC REPORTS,2015,5.
APA	Leung,Hoi-Wing.,Zhao,Si-Meng.,Yue,Grace Gar-Lee.,Lee,Julia Kin-Ming.,Fung,Kwok-Pui.,...&Lau,Clara Bik-San.(2015).RA-XII inhibits tumour growth and metastasis in breast tumour-bearing mice via reducing cell adhesion and invasion and promoting matrix degradation.SCIENTIFIC REPORTS,5.
MLA	Leung,Hoi-Wing,et al."RA-XII inhibits tumour growth and metastasis in breast tumour-bearing mice via reducing cell adhesion and invasion and promoting matrix degradation".SCIENTIFIC REPORTS 5(2015).

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