Synthesis, Anti-tumor Activity and Odd-even Effect of Simple Isatin Derivatives

doi:10.2174/157018081210151012120940

	Synthesis, Anti-tumor Activity and Odd-even Effect of Simple Isatin Derivatives
	Chen, Gang 1,2; Hao, Xiaojiang2,3,4 ; Wang, Ye 3,4; Mu, Shuzhen 3,4
	2015
发表期刊	LETTERS IN DRUG DESIGN & DISCOVERY
卷号	12 期号:10 页码:813-818
摘要	In this work, a series of N-substituted isatin derivatives was synthesized by different reactions. The synthesized isatin derivatives were characterized by NMR, MS and elemental analysis. Then the anti-tumor activities of these compounds were evaluated through the cytotoxicity against A549 and P388 cell line test. The results show that several compounds show much higher anti-tumor activity than that of isatin, and there is an even-odd effect in the structure activity relationship.
关键词	Isatin Derivative Synthesis Anti-tumor Neuro-protection Even-odd Effect
DOI	10.2174/157018081210151012120940
收录类别	SCI
语种	英语
WOS记录号	WOS:000364520600004
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/25235
专题	植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Xian Shiyou Univ, Coll Chem & Chem Engn, Xian 701165, Shaanxi, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China 3.Key Lab Chem Nat Prod Guizhou Prov, Guiyang 550002, Peoples R China 4.Chinese Acad Sci, Guiyang 550002, Peoples R China
推荐引用方式 GB/T 7714	Chen, Gang,Hao, Xiaojiang,Wang, Ye,et al. Synthesis, Anti-tumor Activity and Odd-even Effect of Simple Isatin Derivatives[J]. LETTERS IN DRUG DESIGN & DISCOVERY,2015,12(10):813-818.
APA	Chen, Gang,Hao, Xiaojiang,Wang, Ye,&Mu, Shuzhen.(2015).Synthesis, Anti-tumor Activity and Odd-even Effect of Simple Isatin Derivatives.LETTERS IN DRUG DESIGN & DISCOVERY,12(10),813-818.
MLA	Chen, Gang,et al."Synthesis, Anti-tumor Activity and Odd-even Effect of Simple Isatin Derivatives".LETTERS IN DRUG DESIGN & DISCOVERY 12.10(2015):813-818.

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