Synthesis, Anti-tumor Activity and Odd-even Effect of Simple Isatin Derivatives
Chen, Gang1,2; Hao, Xiaojiang2,3,4; Wang, Ye3,4; Mu, Shuzhen3,4
2015
发表期刊LETTERS IN DRUG DESIGN & DISCOVERY
卷号12期号:10页码:813-818
摘要In this work, a series of N-substituted isatin derivatives was synthesized by different reactions. The synthesized isatin derivatives were characterized by NMR, MS and elemental analysis. Then the anti-tumor activities of these compounds were evaluated through the cytotoxicity against A549 and P388 cell line test. The results show that several compounds show much higher anti-tumor activity than that of isatin, and there is an even-odd effect in the structure activity relationship.
关键词Isatin Derivative Synthesis Anti-tumor Neuro-protection Even-odd Effect
DOI10.2174/157018081210151012120940
收录类别SCI
语种英语
WOS记录号WOS:000364520600004
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/25235
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Xian Shiyou Univ, Coll Chem & Chem Engn, Xian 701165, Shaanxi, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China
3.Key Lab Chem Nat Prod Guizhou Prov, Guiyang 550002, Peoples R China
4.Chinese Acad Sci, Guiyang 550002, Peoples R China
推荐引用方式
GB/T 7714
Chen, Gang,Hao, Xiaojiang,Wang, Ye,et al. Synthesis, Anti-tumor Activity and Odd-even Effect of Simple Isatin Derivatives[J]. LETTERS IN DRUG DESIGN & DISCOVERY,2015,12(10):813-818.
APA Chen, Gang,Hao, Xiaojiang,Wang, Ye,&Mu, Shuzhen.(2015).Synthesis, Anti-tumor Activity and Odd-even Effect of Simple Isatin Derivatives.LETTERS IN DRUG DESIGN & DISCOVERY,12(10),813-818.
MLA Chen, Gang,et al."Synthesis, Anti-tumor Activity and Odd-even Effect of Simple Isatin Derivatives".LETTERS IN DRUG DESIGN & DISCOVERY 12.10(2015):813-818.
条目包含的文件 下载所有文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
006AJ.pdf(1098KB)期刊论文作者接受稿开放获取CC BY-NC-SA浏览 下载
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Chen, Gang]的文章
[Hao, Xiaojiang]的文章
[Wang, Ye]的文章
百度学术
百度学术中相似的文章
[Chen, Gang]的文章
[Hao, Xiaojiang]的文章
[Wang, Ye]的文章
必应学术
必应学术中相似的文章
[Chen, Gang]的文章
[Hao, Xiaojiang]的文章
[Wang, Ye]的文章
相关权益政策
暂无数据
收藏/分享
文件名: 006AJ.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。