Cytotoxic limonoids from Trichilia americana leaves
Ji,Kai-Long; Zhang,Ping; Li,Xiao-Nian; Guo,Juan; Hu,Hua-Bin; Xiao,Chun-Fen; Xie,Xiang-Qun; Xu,You-Kai
2015-10-01
Source PublicationPHYTOCHEMISTRY
Volume118Pages:61-67
AbstractTen cedrelone limonoids were isolated from the leaves of Trichilia americana. These compounds include americanolides A-D (1-4), 1,2-dihydrodeacetylhirtin (5), 1 alpha-hydroxy-1,2-dihydrodeacetylhirtin (6), 1ahydroxy-1,2-dihydrohirtin (7), 1 alpha-methoxy-1,2-dihydrodeacetylhirtin (8), 11 beta-hydroxy-12 alpha-propanoyloxycedrelone (9), and 1 alpha,11 beta-dihydroxy-1,2-dihydrocedrelone (10), as well as two previously reported compounds, deacetylhirtin (11) and hirtin (12). Their structures were characterized on the basis of spectroscopic studies, and the assignment of the absolute configuration of americanolide A (1) was supported by single-crystal X-ray diffraction studies. The cytotoxic activities of all isolated compounds were also evaluated against five human tumour cell lines (HL-60, SMMC-7721, A-549, MCF-7, and SW-480) using an MTS assay. Compounds 11 and 12 showed significant cytotoxicity with IC50 values ranging from 0.1 to 0.5 mu M, and compounds 5, 6, 7, 8, 9, and 10 exhibited potent or selective cytotoxic activity with IC50 values ranging from 1.0 to 39.6 mu M. (C) 2015 Elsevier Ltd. All rights reserved.
KeywordTrichilia Americana Meliaceae Cedrelone Limonoids Cytotoxicity
DOI10.1016/j.phytochem.2015.08.014
Indexed BySCI
Language英语
WOS IDWOS:000363076800008
Citation statistics
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/25206
Collection植物化学与西部植物资源持续利用国家重点实验室
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GB/T 7714
Ji,Kai-Long,Zhang,Ping,Li,Xiao-Nian,et al. Cytotoxic limonoids from Trichilia americana leaves[J]. PHYTOCHEMISTRY,2015,118:61-67.
APA Ji,Kai-Long.,Zhang,Ping.,Li,Xiao-Nian.,Guo,Juan.,Hu,Hua-Bin.,...&Xu,You-Kai.(2015).Cytotoxic limonoids from Trichilia americana leaves.PHYTOCHEMISTRY,118,61-67.
MLA Ji,Kai-Long,et al."Cytotoxic limonoids from Trichilia americana leaves".PHYTOCHEMISTRY 118(2015):61-67.
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