Cytotoxic limonoids from Trichilia americana leaves

doi:10.1016/j.phytochem.2015.08.014

	Cytotoxic limonoids from Trichilia americana leaves
	Ji,Kai-Long; Zhang,Ping; Li,Xiao-Nian; Guo,Juan; Hu,Hua-Bin; Xiao,Chun-Fen; Xie,Xiang-Qun; Xu,You-Kai
	2015-10-01
发表期刊	PHYTOCHEMISTRY
卷号	118 页码:61-67
摘要	Ten cedrelone limonoids were isolated from the leaves of Trichilia americana. These compounds include americanolides A-D (1-4), 1,2-dihydrodeacetylhirtin (5), 1 alpha-hydroxy-1,2-dihydrodeacetylhirtin (6), 1ahydroxy-1,2-dihydrohirtin (7), 1 alpha-methoxy-1,2-dihydrodeacetylhirtin (8), 11 beta-hydroxy-12 alpha-propanoyloxycedrelone (9), and 1 alpha,11 beta-dihydroxy-1,2-dihydrocedrelone (10), as well as two previously reported compounds, deacetylhirtin (11) and hirtin (12). Their structures were characterized on the basis of spectroscopic studies, and the assignment of the absolute configuration of americanolide A (1) was supported by single-crystal X-ray diffraction studies. The cytotoxic activities of all isolated compounds were also evaluated against five human tumour cell lines (HL-60, SMMC-7721, A-549, MCF-7, and SW-480) using an MTS assay. Compounds 11 and 12 showed significant cytotoxicity with IC50 values ranging from 0.1 to 0.5 mu M, and compounds 5, 6, 7, 8, 9, and 10 exhibited potent or selective cytotoxic activity with IC50 values ranging from 1.0 to 39.6 mu M. (C) 2015 Elsevier Ltd. All rights reserved.
关键词	Trichilia Americana Meliaceae Cedrelone Limonoids Cytotoxicity
DOI	10.1016/j.phytochem.2015.08.014
收录类别	SCI
语种	英语
WOS记录号	WOS:000363076800008
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/25206
专题	植物化学与西部植物资源持续利用国家重点实验室
推荐引用方式 GB/T 7714	Ji,Kai-Long,Zhang,Ping,Li,Xiao-Nian,et al. Cytotoxic limonoids from Trichilia americana leaves[J]. PHYTOCHEMISTRY,2015,118:61-67.
APA	Ji,Kai-Long.,Zhang,Ping.,Li,Xiao-Nian.,Guo,Juan.,Hu,Hua-Bin.,...&Xu,You-Kai.(2015).Cytotoxic limonoids from Trichilia americana leaves.PHYTOCHEMISTRY,118,61-67.
MLA	Ji,Kai-Long,et al."Cytotoxic limonoids from Trichilia americana leaves".PHYTOCHEMISTRY 118(2015):61-67.

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