Iridoids and sesquiterpenoids of Valeriana stenoptera and their effects on NGF-induced neurite outgrowth in PC12 cells
Dong,Fa-Wu; Wu,Zhi-Kun; Yang,Liu; Zi,Chen-Ting; Yang,Dan; Ma,Rui-Jing; Liu,Zhen-Hua; Luo,Huai-Rong; Zhou,Jun; Hu,Jiang-Miao
2015-10-01
Source PublicationPHYTOCHEMISTRY
Volume118Pages:51-60
AbstractTwenty-one compounds (nine iridoids and twelve sesquiterpenoids), including ten previously unknown (five iridoids and five sesquiterpenoids) were isolated from whole dried material of Valeriana stenoptera. Structures were established on the basis of extensive spectroscopic analysis and the relative stereochemistry of 13-hydroxypatchoulol A was further confirmed by X-ray crystallographic data. All isolates were evaluated for their effects on nerve growth factor (NGF)-mediated neurite outgrowth in pheochromocytoma (PC12) cells and seven compounds showed potent promoting effects. (C) 2015 Elsevier Ltd. All rights reserved.
KeywordValeriana Stenoptera Valerianaceae Iridoids Sesquiterpenoids Biological Activity
DOI10.1016/j.phytochem.2015.08.015
Indexed BySCI
Language英语
WOS IDWOS:000363076800007
Citation statistics
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/25201
Collection植物化学与西部植物资源持续利用国家重点实验室
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GB/T 7714
Dong,Fa-Wu,Wu,Zhi-Kun,Yang,Liu,et al. Iridoids and sesquiterpenoids of Valeriana stenoptera and their effects on NGF-induced neurite outgrowth in PC12 cells[J]. PHYTOCHEMISTRY,2015,118:51-60.
APA Dong,Fa-Wu.,Wu,Zhi-Kun.,Yang,Liu.,Zi,Chen-Ting.,Yang,Dan.,...&Hu,Jiang-Miao.(2015).Iridoids and sesquiterpenoids of Valeriana stenoptera and their effects on NGF-induced neurite outgrowth in PC12 cells.PHYTOCHEMISTRY,118,51-60.
MLA Dong,Fa-Wu,et al."Iridoids and sesquiterpenoids of Valeriana stenoptera and their effects on NGF-induced neurite outgrowth in PC12 cells".PHYTOCHEMISTRY 118(2015):51-60.
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