Penicamedine A, a Highly Oxygenated Hexacyclic Indole Alkaloid from Penicillium camemberti

doi:10.1002/cbdv.201400412

	Penicamedine A, a Highly Oxygenated Hexacyclic Indole Alkaloid from Penicillium camemberti
	Zhu,Hucheng; Chen,Chunmei; Wang,Jianping; Li,Xiao-Nian; Wei,Guangzheng; Guo,Yi; Yao,Guangmin; Luo,Zengwei; Zhang,Jinwen; Xue,Yongbo; Zhang,Yonghui
	2015-10-01
发表期刊	CHEMISTRY & BIODIVERSITY
卷号	12 期号:10 页码:1547-1553
摘要	A highly oxygenated hexacyclic indole alkaloid, penicamedine A (1), bearing a rare furan ring, was isolated from the culture broth of Penicillium camemberti, together with two known analogs, iso--cyclopiazonic acid (2) and cyclopiazonic acid (3). The structure of 1 was elucidated by comprehensive spectroscopic analyses including NMR and HR-ESI-MS. Its absolute configuration was further confirmed unambiguously by single-crystal X-ray diffraction analysis. Compound 1 was evaluated for anti-HIV activity with p24 assays and tested for cytotoxic activities against five human cancer cell lines, including HL-60, SMMC-7721, A-549, MCF-7, SW480, and the immortalized non-cancerous human pulmonary epithelial cell line BEAS-2B by MTS method.
关键词	Anti-hiv Activity Cytotoxic Activity Indole Alkaloids Penicamedine a Penicillium Camemberti X-ray Crystallography
DOI	10.1002/cbdv.201400412
收录类别	SCI
语种	英语
WOS记录号	WOS:000362956100006
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/25195
专题	植物化学与西部植物资源持续利用国家重点实验室
推荐引用方式 GB/T 7714	Zhu,Hucheng,Chen,Chunmei,Wang,Jianping,et al. Penicamedine A, a Highly Oxygenated Hexacyclic Indole Alkaloid from Penicillium camemberti[J]. CHEMISTRY & BIODIVERSITY,2015,12(10):1547-1553.
APA	Zhu,Hucheng.,Chen,Chunmei.,Wang,Jianping.,Li,Xiao-Nian.,Wei,Guangzheng.,...&Zhang,Yonghui.(2015).Penicamedine A, a Highly Oxygenated Hexacyclic Indole Alkaloid from Penicillium camemberti.CHEMISTRY & BIODIVERSITY,12(10),1547-1553.
MLA	Zhu,Hucheng,et al."Penicamedine A, a Highly Oxygenated Hexacyclic Indole Alkaloid from Penicillium camemberti".CHEMISTRY & BIODIVERSITY 12.10(2015):1547-1553.

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