Terpenoids with cytotoxic activity from the branches and leaves of Pyrus pashia

doi:10.1016/j.phytol.2015.06.015

	Terpenoids with cytotoxic activity from the branches and leaves of Pyrus pashia
	Lia,Zhen-Jie; Wan,Chun-Ping; Cai,Le; Li,Shu-Quan; Zheng,Xi; Qi,Yan; Dong,Jian-Wei; Yin,Tian-Peng; Zhou,Zhi-Xian; Tan,Ning-Hua; Ding,Zhong-Tao
	2015-09-01
发表期刊	PHYTOCHEMISTRY LETTERS
卷号	13 页码:246-251
摘要	Twenty terpenoids, including a new triterpenoid (1) and a new monoterpenoid (20), were isolated from the branches and leaves of Pyrus pashia. The structures of two new compounds were determined to be 2 alpha, 3 beta, 27-trihydroxyolean-12-en-28-oic acid (1) and (4 alpha)-3-(5,5-dimethyltetrahydrofuranyl)-1-buten-3-ol 3-O-beta-D-glucopyranoside (20) on the basis of spectroscopic analysis (IR, HRESIMS, 1D and 2D NMR) and chemical method. Some of the isolated compounds were evaluated for their cytotoxic activity against a panel of human cancer cell lines by MTT assay, using cisplatin as a positive control. Compound 14 exhibited cytotoxic activities against A549 (IC50 = 19.18 +/- 4.26 mu M), Hela (IC50 = 12.56 +/- 3.89 mu M), SGC7901 (IC50 = 10.48 +/- 1.95 mu M) and NHI-1975 (IC50 = 7.38 +/- 2.31 mu M) cell lines as well as compound 12 displayed cytotoxic activities against A549 (IC50 = 14.71 +/- 1.47 mu M) and Hela (IC50 = 12.22 +/- 1.88 mu M) cell lines. (C) 2015 Published by Elsevier B.V. on behalf of Phytochemical Society of Europe.
关键词	Pyrus Pashia Triterpenoid Monoterpenoid Cytotoxic Activity
DOI	10.1016/j.phytol.2015.06.015
收录类别	SCI
语种	英语
WOS记录号	WOS:000362174600043
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/25167
专题	植物化学与西部植物资源持续利用国家重点实验室
推荐引用方式 GB/T 7714	Lia,Zhen-Jie,Wan,Chun-Ping,Cai,Le,et al. Terpenoids with cytotoxic activity from the branches and leaves of Pyrus pashia[J]. PHYTOCHEMISTRY LETTERS,2015,13:246-251.
APA	Lia,Zhen-Jie.,Wan,Chun-Ping.,Cai,Le.,Li,Shu-Quan.,Zheng,Xi.,...&Ding,Zhong-Tao.(2015).Terpenoids with cytotoxic activity from the branches and leaves of Pyrus pashia.PHYTOCHEMISTRY LETTERS,13,246-251.
MLA	Lia,Zhen-Jie,et al."Terpenoids with cytotoxic activity from the branches and leaves of Pyrus pashia".PHYTOCHEMISTRY LETTERS 13(2015):246-251.

条目包含的文件		下载所有文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可
1-s2.0-S187439001530（529KB）	期刊论文	作者接受稿	开放获取	CC BY-NC-SA	浏览下载