Cytotoxic labdane-type diterpenes from Hedychium longipetalum inhibiting production of nitric oxide
Zhao,Hongmei; Zeng,Guangzhi; Zhao,Simeng; Xu,Junju; Kong,Lingmei; Li,Yan; Tan,Ninghua; Yang,Shengchao
2015-10-15
Source PublicationBIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume25Issue:20Pages:4572-4575
AbstractThree new labdane diterpenes, hedylongnoids A (1), B (2) and C (3), were isolated from the rhizomes of Hedychium longipetalum, together with three known ones yunnancoronarin A (4), hedyforrestin C (5) and hedyforrestin B (6). Their structures were established by spectroscopic analysis, including 2D-NMR spectroscopic techniques. Compounds 1-6 exhibited inhibitory effects against nitric oxide (NO) production in LPS and IFN-gamma-induced RAW 264.7 murine macrophages with IC50 values ranging from 0.56 to 7.50 mu g/ml, and 3-6 showed cytotoxicities against cancer cell lines SGC-7901 and Hela with IC50 values ranging from 6.21 to 14.53 mu g/ml and from 6.58 to 14.83 mu g/ml, respectively. (C) 2015 Elsevier Ltd. All rights reserved.
KeywordZingiberaceae Hedychium Longipetalum Labdane Diterpenes Inhibition Of No Production Cytotoxicity
DOI10.1016/j.bmcl.2015.08.057
Indexed BySCI
Language英语
WOS IDWOS:000362102200039
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Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/25164
Collection植物化学与西部植物资源持续利用国家重点实验室
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GB/T 7714
Zhao,Hongmei,Zeng,Guangzhi,Zhao,Simeng,et al. Cytotoxic labdane-type diterpenes from Hedychium longipetalum inhibiting production of nitric oxide[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2015,25(20):4572-4575.
APA Zhao,Hongmei.,Zeng,Guangzhi.,Zhao,Simeng.,Xu,Junju.,Kong,Lingmei.,...&Yang,Shengchao.(2015).Cytotoxic labdane-type diterpenes from Hedychium longipetalum inhibiting production of nitric oxide.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,25(20),4572-4575.
MLA Zhao,Hongmei,et al."Cytotoxic labdane-type diterpenes from Hedychium longipetalum inhibiting production of nitric oxide".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 25.20(2015):4572-4575.
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