Hyperisampsins H-M, Cytotoxic Polycyclic Polyprenylated Acylphloroglucinols from Hypericum sampsonii

doi:10.1038/srep14772

	Hyperisampsins H-M, Cytotoxic Polycyclic Polyprenylated Acylphloroglucinols from Hypericum sampsonii
	Zhu,Hucheng; Chen,Chunmei; Tong,Qingyi; Chen,Xintao; Yang,Jing; Liu,Junjun; Sun,Bin; Wang,Jianping; Yao,Guangmin; Luo,Zengwei; Xue,Yongbo; Zhang,Yonghui
	2015-10-06
发表期刊	SCIENTIFIC REPORTS
卷号	5
摘要	Six new polycyclic polyprenylated acylphloroglucinols (PPAPs), named hyperisampsins H-M (1-6), were isolated from the aerial parts of Hypericum sampsonii, together with five known analogs (7-11). The structures of 1-6 were established by extensive spectroscopic analyses, including HRESIMS and NMR. In addition, the absolute configurations of these new compounds were determined by electronic circular dichroism (ECD) calculations. Compounds 1 and 2 represent the first examples of PPAPs possessing a unique gamma-lactone ring at C-23, while 3-6 differed from normal PPAPs with an unprecedented 1,2-dioxane ring. Compounds 1-7 were evaluated for their cytotoxic activities against a panel of human cancer cell lines in vitro, of which 3, 4, and 6 exhibited significant cytotoxic activities with IC50 values ranging from 0.56 to 3.00 mu M. Moreover, compound 3 induces leukemia cell apoptotic death, evidenced by activation of caspase-3, degradation of PARP, up-regulation of Bax, and down-regulation of Bcl-2 and Bcl-xl.
DOI	10.1038/srep14772
收录类别	SCI
语种	英语
WOS记录号	WOS:000362260000001
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/25162
专题	植物化学与西部植物资源持续利用国家重点实验室
推荐引用方式 GB/T 7714	Zhu,Hucheng,Chen,Chunmei,Tong,Qingyi,et al. Hyperisampsins H-M, Cytotoxic Polycyclic Polyprenylated Acylphloroglucinols from Hypericum sampsonii[J]. SCIENTIFIC REPORTS,2015,5.
APA	Zhu,Hucheng.,Chen,Chunmei.,Tong,Qingyi.,Chen,Xintao.,Yang,Jing.,...&Zhang,Yonghui.(2015).Hyperisampsins H-M, Cytotoxic Polycyclic Polyprenylated Acylphloroglucinols from Hypericum sampsonii.SCIENTIFIC REPORTS,5.
MLA	Zhu,Hucheng,et al."Hyperisampsins H-M, Cytotoxic Polycyclic Polyprenylated Acylphloroglucinols from Hypericum sampsonii".SCIENTIFIC REPORTS 5(2015).

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