Designed biosynthesis of 25-methyl and 25-ethyl ivermectin with enhanced insecticidal activity by domain swap of avermectin polyketide synthase

doi:10.1186/s12934-015-0337-y

	Designed biosynthesis of 25-methyl and 25-ethyl ivermectin with enhanced insecticidal activity by domain swap of avermectin polyketide synthase
	Zhang,Ji; Yan,Yi-Jun; An,Jing; Huang,Sheng-Xiong; Wang,Xiang-Jing; Xiang,Wen-Sheng
	2015-09-24
发表期刊	MICROBIAL CELL FACTORIES
卷号	14
摘要	Background: Avermectin and milbemycin are important 16-membered macrolides that have been widely used as pesticides in agriculture. However, the wide use of these pesticides inevitably causes serious drug resistance, it is therefore imperative to develop new avermectin and milbemycin analogs. The biosynthetic gene clusters of avermectin and milbemycin have been identified and the biosynthetic pathways have been elucidated. Combinatorial biosynthesis by domain swap provides an efficient strategy to generate chemical diversity according to the module polyketide synthase (PKS) assembly line.
关键词	25-ethyl Ivermectin 25-methyl Ivermectin Domain Swap Insecticidal Activity
DOI	10.1186/s12934-015-0337-y
收录类别	SCI
语种	英语
WOS记录号	WOS:000361650700001
引用统计	被引频次：45[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/25153
专题	植物化学与西部植物资源持续利用国家重点实验室
推荐引用方式 GB/T 7714	Zhang,Ji,Yan,Yi-Jun,An,Jing,et al. Designed biosynthesis of 25-methyl and 25-ethyl ivermectin with enhanced insecticidal activity by domain swap of avermectin polyketide synthase[J]. MICROBIAL CELL FACTORIES,2015,14.
APA	Zhang,Ji,Yan,Yi-Jun,An,Jing,Huang,Sheng-Xiong,Wang,Xiang-Jing,&Xiang,Wen-Sheng.(2015).Designed biosynthesis of 25-methyl and 25-ethyl ivermectin with enhanced insecticidal activity by domain swap of avermectin polyketide synthase.MICROBIAL CELL FACTORIES,14.
MLA	Zhang,Ji,et al."Designed biosynthesis of 25-methyl and 25-ethyl ivermectin with enhanced insecticidal activity by domain swap of avermectin polyketide synthase".MICROBIAL CELL FACTORIES 14(2015).

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