Designed biosynthesis of 25-methyl and 25-ethyl ivermectin with enhanced insecticidal activity by domain swap of avermectin polyketide synthase
Zhang,Ji; Yan,Yi-Jun; An,Jing; Huang,Sheng-Xiong; Wang,Xiang-Jing; Xiang,Wen-Sheng
2015-09-24
发表期刊MICROBIAL CELL FACTORIES
卷号14
摘要Background: Avermectin and milbemycin are important 16-membered macrolides that have been widely used as pesticides in agriculture. However, the wide use of these pesticides inevitably causes serious drug resistance, it is therefore imperative to develop new avermectin and milbemycin analogs. The biosynthetic gene clusters of avermectin and milbemycin have been identified and the biosynthetic pathways have been elucidated. Combinatorial biosynthesis by domain swap provides an efficient strategy to generate chemical diversity according to the module polyketide synthase (PKS) assembly line.
关键词25-ethyl Ivermectin 25-methyl Ivermectin Domain Swap Insecticidal Activity
DOI10.1186/s12934-015-0337-y
收录类别SCI
语种英语
WOS记录号WOS:000361650700001
引用统计
被引频次:42[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/25153
专题植物化学与西部植物资源持续利用国家重点实验室
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GB/T 7714
Zhang,Ji,Yan,Yi-Jun,An,Jing,et al. Designed biosynthesis of 25-methyl and 25-ethyl ivermectin with enhanced insecticidal activity by domain swap of avermectin polyketide synthase[J]. MICROBIAL CELL FACTORIES,2015,14.
APA Zhang,Ji,Yan,Yi-Jun,An,Jing,Huang,Sheng-Xiong,Wang,Xiang-Jing,&Xiang,Wen-Sheng.(2015).Designed biosynthesis of 25-methyl and 25-ethyl ivermectin with enhanced insecticidal activity by domain swap of avermectin polyketide synthase.MICROBIAL CELL FACTORIES,14.
MLA Zhang,Ji,et al."Designed biosynthesis of 25-methyl and 25-ethyl ivermectin with enhanced insecticidal activity by domain swap of avermectin polyketide synthase".MICROBIAL CELL FACTORIES 14(2015).
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