Cytotoxic diterpenoids from Jatropha curcas cv. nigroviensrugosus CY Yang Roots

doi:10.1016/j.phytochem.2015.07.002

	Cytotoxic diterpenoids from Jatropha curcas cv. nigroviensrugosus CY Yang Roots
	Liu,JieQing; Yang,YuanFeng; Xia,JianJun; Li,XuYang; Li,ZhongRong; Zhou,Lin; Qiu,MingHua
	2015-09-01
发表期刊	PHYTOCHEMISTRY
卷号	117 页码:462-468
摘要	An investigation of phytochemicals from the roots of Jatropha curcas cv. nigroviensrugosus resulted in the isolation of twenty diterpenoids, including lathyranlactone, an unusual diterpenoid lactone possessing a 5/13/3 tricyclic skeleton, jatrocurcasenones A-E and jatrophodiones B-E, as well as 10 known analogues. All isolates were evaluated for cytotoxicity against the HL-60, SMMC-772, A-549, MCF-7 and SW480 human tumor cell lines using the MTS viability assay. Four of the known analogues showed cytotoxic activity in these cell lines, with IC50 values ranging from 2.0 to 23.0 mu M. Moreover, the assessment of their cytotoxic structure-activity relationships showed the epoxy ring between C-5 and C-6 and the hydroxyl group at C-2 were the key functionalities for cytotoxicity. (C) 2015 Elsevier Ltd. All rights reserved.
关键词	Jatropha Curcas Euphorbiaceae Diterpenoids Cytotoxic Activity
DOI	10.1016/j.phytochem.2015.07.002
收录类别	SCI
语种	英语
WOS记录号	WOS:000361253300047
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/25142
专题	植物化学与西部植物资源持续利用国家重点实验室
推荐引用方式 GB/T 7714	Liu,JieQing,Yang,YuanFeng,Xia,JianJun,et al. Cytotoxic diterpenoids from Jatropha curcas cv. nigroviensrugosus CY Yang Roots[J]. PHYTOCHEMISTRY,2015,117:462-468.
APA	Liu,JieQing.,Yang,YuanFeng.,Xia,JianJun.,Li,XuYang.,Li,ZhongRong.,...&Qiu,MingHua.(2015).Cytotoxic diterpenoids from Jatropha curcas cv. nigroviensrugosus CY Yang Roots.PHYTOCHEMISTRY,117,462-468.
MLA	Liu,JieQing,et al."Cytotoxic diterpenoids from Jatropha curcas cv. nigroviensrugosus CY Yang Roots".PHYTOCHEMISTRY 117(2015):462-468.

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