| Effects of arachidonic acid intake on inflammatory reactions in dextran sodium sulphate-induced colitis in rats | |
Naito,Yukiko; Ji,Xu ; Tachibana,Shigehiro; Aoki,Satoko; Furuya,Mami; Tazura,Yoshiyuki; Miyazawa,Daisuke; Harauma,Akiko; Moriguchi,Toru; Nagata,Tomoko; Iwai,Naoharu; Ohara,Naoki
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| 2015-09-14 | |
| 发表期刊 | BRITISH JOURNAL OF NUTRITION
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| 卷号 | 114期号:5页码:734-745 |
| 摘要 | The aim of this study was to investigate the effects of the administration of oral arachidonic acid (AA) in rats with or without dextran sulphate sodium (DSS)-induced inflammatory bowel disease. Male Wistar rats were administered AA at 0, 5, 35 or 240 mg/kg daily by gavage for 8 weeks. Inflammatory bowel disease was induced by replacing drinking water with 3 % DSS solution during the last 7 d of the AA dosing period. These animals passed loose stools, diarrhoea and red-stained faeces. Cyclo-oxygenase-2 concentration and myeloperoxidase activity in the colonic tissue were significantly increased in the animals given AA at 240 mg/kg compared with the animals given AA at 0 mg/kg. Thromboxane B-2 concentration in the medium of cultured colonic mucosae isolated from these groups was found to be dose-dependently increased by AA, and the increase was significant at 35 and 240 mg/kg. Leukotriene B-4 concentration was also significantly increased and saturated at 5 mg/kg. In addition, AA at 240 mg/kg promoted DSS-induced colonic mucosal oedema with macrophage infiltration. In contrast, administration of AA for 8 weeks, even at 240 mg/kg, showed no effects on the normal rats. These results suggest that in rats with bowel disease AA metabolism is affected by oral AA, even at 5 mg/kg per d, and that excessive AA may aggravate inflammation, whereas AA shows no effects in rats without inflammatory bowel disease. |
| 关键词 | Arachidonic Acid Colitis Dextran Sodium Sulphate Supplementation |
| DOI | 10.1017/S000711451500224X |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000360579900009 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/25115 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Naito,Yukiko,Ji,Xu,Tachibana,Shigehiro,et al. Effects of arachidonic acid intake on inflammatory reactions in dextran sodium sulphate-induced colitis in rats[J]. BRITISH JOURNAL OF NUTRITION,2015,114(5):734-745. |
| APA | Naito,Yukiko.,Ji,Xu.,Tachibana,Shigehiro.,Aoki,Satoko.,Furuya,Mami.,...&Ohara,Naoki.(2015).Effects of arachidonic acid intake on inflammatory reactions in dextran sodium sulphate-induced colitis in rats.BRITISH JOURNAL OF NUTRITION,114(5),734-745. |
| MLA | Naito,Yukiko,et al."Effects of arachidonic acid intake on inflammatory reactions in dextran sodium sulphate-induced colitis in rats".BRITISH JOURNAL OF NUTRITION 114.5(2015):734-745. |
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