Synthesis of 4-ethyl-5-methyl-5,6-dihydrophenanthridine-8,9-diol as the key intermediate of potent agonists of the Wnt signalling pathway

doi:10.3184/174751915X14285852307852

	Synthesis of 4-ethyl-5-methyl-5,6-dihydrophenanthridine-8,9-diol as the key intermediate of potent agonists of the Wnt signalling pathway
	Jing, Chen-xu; Cai, Jie-yun; Zhang, Yu; Chen, Duo-zhi; Hao, Xiao-jiang
	2015-04-01
发表期刊	JOURNAL OF CHEMICAL RESEARCH
期号	4 页码:247-250
摘要	The synthesis of 4-ethyl-5-methyl-5,6-dihydro-phenanthridine-8,9-diol as the key intermediate of a series of potent Wnt signalling pathway agonists is reported. This synthesis features a consecutive aryl-aryl and N-aryl coupling, leading to 4-ethyl-5-methyl-8,9-dimethoxyphenanthridin- 6-(5H)-one, whose structure was determined by spectroscopic analysis and X-ray crystallography, in a one-pot sequence with the presence of palladium catalyst and TFP (tri(2-furyl)phosphine) as the ligand.
关键词	Phenanthridin Palladium Catalyst Aryl-aryl Coupling N-aryl Coupling
DOI	10.3184/174751915X14285852307852
收录类别	SCI
语种	英语
WOS记录号	WOS:000360201000016
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/25110
专题	植物化学与西部植物资源持续利用国家重点实验室
推荐引用方式 GB/T 7714	Jing, Chen-xu,Cai, Jie-yun,Zhang, Yu,et al. Synthesis of 4-ethyl-5-methyl-5,6-dihydrophenanthridine-8,9-diol as the key intermediate of potent agonists of the Wnt signalling pathway[J]. JOURNAL OF CHEMICAL RESEARCH,2015(4):247-250.
APA	Jing, Chen-xu,Cai, Jie-yun,Zhang, Yu,Chen, Duo-zhi,&Hao, Xiao-jiang.(2015).Synthesis of 4-ethyl-5-methyl-5,6-dihydrophenanthridine-8,9-diol as the key intermediate of potent agonists of the Wnt signalling pathway.JOURNAL OF CHEMICAL RESEARCH(4),247-250.
MLA	Jing, Chen-xu,et al."Synthesis of 4-ethyl-5-methyl-5,6-dihydrophenanthridine-8,9-diol as the key intermediate of potent agonists of the Wnt signalling pathway".JOURNAL OF CHEMICAL RESEARCH .4(2015):247-250.

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