New cytotoxic and anti-inflammatory compounds isolated from Morus alba L.
Qin,Jing; Fan,Min; He,Juan; Wu,Xing-De; Peng,Li-Yan; Su,Jia; Cheng,Xiao; Li,Yan; Kong,Ling-Mei; Li,Rong-Tao; Zhao,Qin-Shi
AbstractSix Diels-Alder adducts (1-6) and nine prenylated flavanones (7-15) were isolated from the root bark of Morus alba L. Among them, soroceal B (1) and sanggenol Q (7) were new compounds. Their structures were elucidated on the basis of extensive spectroscopic methods, including 1D and 2D NMR techniques. Compounds 1-3, 9, 10, 12, 13 and 15 exhibited cytotoxic activity against five human tumour lines and compound 2 inhibited significantly selective cytotoxic activities towards HL-60 and AGS cells with IC50 of 3.4 and 3.6M. Compounds 3, 5, 9 and 12 exhibited moderate inhibitory activity against nitric oxide production in LPS-activated RAW264.7.
KeywordMorus Alba l Soroceal b Sanggenol q Cytotoxic Activity Anti-inflammatory Activity
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WOS IDWOS:000359849800004
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Qin,Jing,Fan,Min,He,Juan,et al. New cytotoxic and anti-inflammatory compounds isolated from Morus alba L.[J]. NATURAL PRODUCT RESEARCH,2015,29(18):1711-1718.
APA Qin,Jing.,Fan,Min.,He,Juan.,Wu,Xing-De.,Peng,Li-Yan.,...&Zhao,Qin-Shi.(2015).New cytotoxic and anti-inflammatory compounds isolated from Morus alba L..NATURAL PRODUCT RESEARCH,29(18),1711-1718.
MLA Qin,Jing,et al."New cytotoxic and anti-inflammatory compounds isolated from Morus alba L.".NATURAL PRODUCT RESEARCH 29.18(2015):1711-1718.
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