Synthesis and antitumor activity of novel N-substituted carbazole imidazolium salt derivatives
Liu, Lan-Xiang; Wang, Xue-Quan; Zhou, Bei; Yang, Li-Juan; Li, Yan; Zhang, Hong-Bin; Yang, Xiao-Dong
2015-08-19
Source PublicationSCIENTIFIC REPORTS
Volume5
AbstractA series of novel N-substituted carbazole imidazolium salt derivatives has been prepared and investigated for their cytotoxic activity against five human tumor cell lines by MTS assay. The results indicated that the existence of 5,6-dimethyl-benzimidazole ring, substitution of the imidazolyl-3-position with a 2-bromobenzyl or naphthylacyl group, as well as alkyl chain length between carbazole and imidazole ring were important for the antitumor activity. Compound 61, bearing a 2-bromobenzyl substituent at position-3 of the 5,6-dimethyl-benzimidazole, showed powerful inhibitory activities and was more selective to HL-60, SMMC-7721, MCF-7 and SW480 cell lines with IC50 values 0.51-2.48 mu M. Mechanism of action studies revealed that this new compound could remarkably induce cell cycle arrest and apoptosis in SMMC-7721 cells. This work provides alternative novel way for future drug development based on carbazole and imidazolium salt scaffolds.
DOI10.1038/srep13101
Indexed BySCI
Language英语
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:000359692000001
Citation statistics
Cited Times:30[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/25098
Collection植物化学与西部植物资源持续利用国家重点实验室
Recommended Citation
GB/T 7714
Liu, Lan-Xiang,Wang, Xue-Quan,Zhou, Bei,et al. Synthesis and antitumor activity of novel N-substituted carbazole imidazolium salt derivatives[J]. SCIENTIFIC REPORTS,2015,5.
APA Liu, Lan-Xiang.,Wang, Xue-Quan.,Zhou, Bei.,Yang, Li-Juan.,Li, Yan.,...&Yang, Xiao-Dong.(2015).Synthesis and antitumor activity of novel N-substituted carbazole imidazolium salt derivatives.SCIENTIFIC REPORTS,5.
MLA Liu, Lan-Xiang,et al."Synthesis and antitumor activity of novel N-substituted carbazole imidazolium salt derivatives".SCIENTIFIC REPORTS 5(2015).
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