Design, Synthesis and Cytotoxic Activity of Novel Hybrid Compounds between Aza-brazilin and Imidazolium

doi:10.6023/cjoc201412055

	Design, Synthesis and Cytotoxic Activity of Novel Hybrid Compounds between Aza-brazilin and Imidazolium
	Wang Xuequan; Li Yan; Yang Xiaodong; Zhang Hongbin
	2015-06-01
发表期刊	CHINESE JOURNAL OF ORGANIC CHEMISTRY
卷号	35 期号:6 页码:1276-1285
摘要	A series of novel hybrid compounds between aza-brazilin and imidazole have been prepared from 3-(3,4-dimeth-oxyphenyl)propanoic acid. Their structures were confirmed by H-1 NMR, C-13 NMR, HR-ESI-MS and X-ray crystallographic analysis. These compounds have been evaluated in vitro against a panel of human tumor cell lines. 2-Methyl-3-(naphthalen-2-ylmethyl)-1-(2-oxo-2-(4,9,10-trimethoxy-6,6a,7,11b-tetrahydro-5H-indeno [2,1-c] quinolin-5-yl)ethyl)-1H-benzo [d]imidazol-3-ium bromide (26) was found to be the most potent derivative against four strains human tumor lines and more active than cisplatin, and exhibited the most potent cytotoxic activities selectively against HL-60, MCF-7 and SW-480.
关键词	Aza-brazilin Imidazole Hybrid Compound Cytotoxic Activity
DOI	10.6023/cjoc201412055
收录类别	SCI
语种	英语
WOS记录号	WOS:000359274400009
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/25090
专题	植物化学与西部植物资源持续利用国家重点实验室
推荐引用方式 GB/T 7714	Wang Xuequan,Li Yan,Yang Xiaodong,et al. Design, Synthesis and Cytotoxic Activity of Novel Hybrid Compounds between Aza-brazilin and Imidazolium[J]. CHINESE JOURNAL OF ORGANIC CHEMISTRY,2015,35(6):1276-1285.
APA	Wang Xuequan,Li Yan,Yang Xiaodong,&Zhang Hongbin.(2015).Design, Synthesis and Cytotoxic Activity of Novel Hybrid Compounds between Aza-brazilin and Imidazolium.CHINESE JOURNAL OF ORGANIC CHEMISTRY,35(6),1276-1285.
MLA	Wang Xuequan,et al."Design, Synthesis and Cytotoxic Activity of Novel Hybrid Compounds between Aza-brazilin and Imidazolium".CHINESE JOURNAL OF ORGANIC CHEMISTRY 35.6(2015):1276-1285.

条目包含的文件		下载所有文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可
合成及细胞毒活性研究.pdf（566KB）	期刊论文	作者接受稿	开放获取	CC BY-NC-SA	浏览下载