Six new cytotoxic and anti-inflammatory 11, 20-epoxy-ent-kaurane diterpenoids from Isodon wikstroemioides

doi:10.3724/SP.J.1009.2015.00383

	Six new cytotoxic and anti-inflammatory 11, 20-epoxy-ent-kaurane diterpenoids from Isodon wikstroemioides
	Wu, H. Y.; Wang, W. G.; Du, X.; Yang, J.; Sun, H. D.
	2015
发表期刊	CHINESE JOURNAL OF NATURAL MEDICINES
卷号	13 期号:5 页码:383-389
摘要	The present study was designed to determine the chemical constituents of EtOAc extracts of the aerial parts of Isodon wikstroemioides. Compounds 1-8 were isolated and purified by normal-phase silica gel and reversed-phase C-18 silica gel column chromatography and HPLC. Their structures were elucidated by extensive spectroscopic methods. Most of them were evaluated for their in vitro cytotoxicity against human cancer HL-60, SMMC-7721, A-549, MCF-7, and SW-480 cells and their inhibitory activity against nitric oxide (NO) production in LPS-activated RAW264.7 macrophages. Among the eight 11, 20-epoxy-ent-kauranoids isolated, compounds 1-6 (isowikstroemins H-M) were new diterpenoids. Compounds 1, 3, and 7 exhibited significant cytotoxicity with IC50 values ranging from (0.84 +/- 0.02) to (4.09 +/- 0.34) mu mol.L-1, while compounds 4 and 5 showed selective cytotoxicity. In addition, compounds 1, 3, 4, and 7 exhibited inhibitory activity against nitric oxide (NO) production in LPS-activated RAW264.7 macrophages. These results provide a basis for future development of these compounds as anti-cancer and anti-inflammatory agents.
关键词	Isodon Wikstroemioides Isowikstroemins H-m Cytotoxicity Anti-inflammatory Activity
DOI	10.3724/SP.J.1009.2015.00383
收录类别	SCI
语种	英语
WOS记录号	WOS:000366435000007
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/25073
专题	植物化学与西部植物资源持续利用国家重点实验室
推荐引用方式 GB/T 7714	Wu, H. Y.,Wang, W. G.,Du, X.,et al. Six new cytotoxic and anti-inflammatory 11, 20-epoxy-ent-kaurane diterpenoids from Isodon wikstroemioides[J]. CHINESE JOURNAL OF NATURAL MEDICINES,2015,13(5):383-389.
APA	Wu, H. Y.,Wang, W. G.,Du, X.,Yang, J.,&Sun, H. D..(2015).Six new cytotoxic and anti-inflammatory 11, 20-epoxy-ent-kaurane diterpenoids from Isodon wikstroemioides.CHINESE JOURNAL OF NATURAL MEDICINES,13(5),383-389.
MLA	Wu, H. Y.,et al."Six new cytotoxic and anti-inflammatory 11, 20-epoxy-ent-kaurane diterpenoids from Isodon wikstroemioides".CHINESE JOURNAL OF NATURAL MEDICINES 13.5(2015):383-389.

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