| Novel 3-substituted fluorine imidazolium/triazolium salt derivatives: synthesis and antitumor activity | |
Liu, Jin-Mei1; Wang, Min2; Zhou, Yun-Jing1; Yan, Ju-Ming2; Yang, Li-Juan3,4; Li, Yan2 ; Zhang, Hong-Bin1; Yang, Xiao-Dong1
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| 2015 | |
| 发表期刊 | RSC ADVANCES
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| 卷号 | 5期号:78页码:63936-63944 |
| 摘要 | A series of novel (+/-)-3-substituted fluorene-imidazolium/triazolium salt derivatives has been prepared and evaluated in vitro against a panel of human tumor cell lines. The results suggest that the existence of 2-methyl-benzimidazole or 5,6-dimethyl-benzimidazole rings and substitution of the imidazolyl/triazolyl3/4-position with a naphthylacyl or 4-methoxyphenacyl group were important for modulating cytotoxic activity. Compounds 37 and 42 were found to be the most potent derivatives with IC50 values of 0.51-2.51 mu M and exhibited cytotoxic activities selectively against myeloid leukaemia (HL-60), liver carcinoma (SMMC-7721) and lung carcinoma (A549). Compound 37 can remarkably induce the G2/M phase cell cycle arrest and apoptosis in SMMC-7721 cells. Additionally, compound 30 exhibited selective cytotoxicity to some extent between cancer cells (A549) and normal cells (BEAS-2B). |
| DOI | 10.1039/c5ra07947k |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000358734800096 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/25072 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Yunnan Univ, Sch Chem Sci & Technol, Key Lab Med Chem Nat Resource, Minist Educ, Kunming 650091, Peoples R China 2.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources West Ch, Kunming Inst Bot, Kunming 650204, Peoples R China 3.Yunnan Minzu Univ, Key Lab Ethn Med Resource Chem, State Ethn Affairs Commiss, Kunming 650500, Peoples R China 4.Yunnan Minzu Univ, Minist Educ, Kunming 650500, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Jin-Mei,Wang, Min,Zhou, Yun-Jing,et al. Novel 3-substituted fluorine imidazolium/triazolium salt derivatives: synthesis and antitumor activity[J]. RSC ADVANCES,2015,5(78):63936-63944. |
| APA | Liu, Jin-Mei.,Wang, Min.,Zhou, Yun-Jing.,Yan, Ju-Ming.,Yang, Li-Juan.,...&Yang, Xiao-Dong.(2015).Novel 3-substituted fluorine imidazolium/triazolium salt derivatives: synthesis and antitumor activity.RSC ADVANCES,5(78),63936-63944. |
| MLA | Liu, Jin-Mei,et al."Novel 3-substituted fluorine imidazolium/triazolium salt derivatives: synthesis and antitumor activity".RSC ADVANCES 5.78(2015):63936-63944. |
| 条目包含的文件 | ||||||
| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
| liu2015.pdf（1168KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | 浏览 下载 | |
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