Isolation and anti-hepatitis B virus activity of dibenzocyclooctadiene lignans from the fruits of Schisandra chinensis

doi:10.1016/j.phytochem.2015.03.009

	Isolation and anti-hepatitis B virus activity of dibenzocyclooctadiene lignans from the fruits of Schisandra chinensis
	Xue, Yongbo; Li, Xifeng; Du, Xue; Li, Xiaonian; Wang, Weiguang; Yang, Jianhong; Chen, Jijun; Pu, Jianxin; Sun, Handong
	2015-08-01
发表期刊	PHYTOCHEMISTRY
卷号	116 页码:253-261
摘要	Seven lignans with a dibenzocyclooctadiene skeleton, termed schinlignans A-G, and a 6,7-seco-homolignan, schischinone, together with seven known lignans, were isolated from the fruits of Schisandra chinensis (Turcz.) Baill. Their structures were elucidated by extensive spectroscopic methods, including HRESIMS, IR, UV, and 2D NMR (COSY, HMQC, COSY, and HMBC experiments). The stereochemistry at the chiral centers and the biphenyl moiety, were determined using ROESY, as well as via interpretation of their ECD spectra. Schinlignan G and methylgomisin O exhibited potent anti-hepatitis B virus activity against HBV DNA replication with IC50 values of 5.13 and 5.49 mu g mL(-1), respectively. (C) 2015 Elsevier Ltd. All rights reserved.
关键词	Schisandra Chinensis Schisandraceae Dibenzocyclooctadiene Lignans Hepatitis b Virus 6 7-seco-homolignan
DOI	10.1016/j.phytochem.2015.03.009
收录类别	SCI
语种	英语
WOS记录号	WOS:000357438200028
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/24977
专题	植物化学与西部植物资源持续利用国家重点实验室
推荐引用方式 GB/T 7714	Xue, Yongbo,Li, Xifeng,Du, Xue,et al. Isolation and anti-hepatitis B virus activity of dibenzocyclooctadiene lignans from the fruits of Schisandra chinensis[J]. PHYTOCHEMISTRY,2015,116:253-261.
APA	Xue, Yongbo.,Li, Xifeng.,Du, Xue.,Li, Xiaonian.,Wang, Weiguang.,...&Sun, Handong.(2015).Isolation and anti-hepatitis B virus activity of dibenzocyclooctadiene lignans from the fruits of Schisandra chinensis.PHYTOCHEMISTRY,116,253-261.
MLA	Xue, Yongbo,et al."Isolation and anti-hepatitis B virus activity of dibenzocyclooctadiene lignans from the fruits of Schisandra chinensis".PHYTOCHEMISTRY 116(2015):253-261.

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