Hyperascyrones A-H, polyprenylated spirocyclic acylphloroglucinol derivatives from Hypericum ascyron Linn.

doi:10.1016/j.phytochem.2015.02.009

	Hyperascyrones A-H, polyprenylated spirocyclic acylphloroglucinol derivatives from Hypericum ascyron Linn.
	Zhu, Hucheng; Chen, Chunmei; Liu, Junjun; Sun, Bin; Wei, Guangzheng; Li, Yan; Zhang, Jinwen; Yao, Guangmin; Luo, Zengwei; Xue, Yongbo; Zhang, Yonghui
	2015-07-01
发表期刊	PHYTOCHEMISTRY
卷号	115 页码:222-230
摘要	Eight polyprenylated spirocyclic acylphloroglucinol derivatives (PSAPs), hyperascyrones A-H, were isolated from the aerial parts of Hypericum ascyron Linn., together with six known analogs. Their structures were established by spectroscopic analyses including HRESIMS, 1D and 2D NMR, and their absolute configurations were determined by electronic circular dichroism calculations (ECD, Gaussian 09). Structures of previously reported tomoeones C, D, G, and H were revised. Hyperascyrones A-H were evaluated for their cytotoxic and anti-HIV-1 activities, with hyperascyrones C and G exhibiting significant cytotoxicities against HL-60 cell lines with IC50 values of 4.22 and 8.36 mu M, respectively. In addition, the chemotaxonomic significance of these compounds was also discussed. (C) 2015 Elsevier Ltd. All rights reserved.
关键词	Hypericum Ascyron Linn. Hypericaceae Polycyclic Polyprenylated Acylphloroglucinols Polyprenylated Spirocyclic Acylphloroglucinol Derivatives Cytotoxic Activities Anti-hiv-1 Activities
DOI	10.1016/j.phytochem.2015.02.009
收录类别	SCI
语种	英语
WOS记录号	WOS:000357237900022
引用统计	被引频次：45[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/24973
专题	植物化学与西部植物资源持续利用国家重点实验室
推荐引用方式 GB/T 7714	Zhu, Hucheng,Chen, Chunmei,Liu, Junjun,et al. Hyperascyrones A-H, polyprenylated spirocyclic acylphloroglucinol derivatives from Hypericum ascyron Linn.[J]. PHYTOCHEMISTRY,2015,115:222-230.
APA	Zhu, Hucheng.,Chen, Chunmei.,Liu, Junjun.,Sun, Bin.,Wei, Guangzheng.,...&Zhang, Yonghui.(2015).Hyperascyrones A-H, polyprenylated spirocyclic acylphloroglucinol derivatives from Hypericum ascyron Linn..PHYTOCHEMISTRY,115,222-230.
MLA	Zhu, Hucheng,et al."Hyperascyrones A-H, polyprenylated spirocyclic acylphloroglucinol derivatives from Hypericum ascyron Linn.".PHYTOCHEMISTRY 115(2015):222-230.

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