| 4-arylcoumarin inhibits immediate-type allergy | |
| Taechowisan, Thongchai; Lu, Chunhua2; Shen, Yuemao3; Lumyong, Saisamorn4 | |
| 2007 | |
| 发表期刊 | FOOD AND AGRICULTURAL IMMUNOLOGY
 |
| 卷号 | 18期号:3-4页码:203-211 |
| 摘要 | This study was undertaken to investigate the effect of 4-arylcoumarin (5,7-dimethoxy-4-p-methoxyphenylcoumarin; MPC) on immediate-type allergic reaction and inflammatory cytokine secretion. MPC inhibited compound 48/80-induced systemic reactions in mice. When MPC was given as a pretreatment at concentrations ranging from 0.001 to 1 g/kg, the serum histamine levels induced by compound 48/80 were reduced in a dose-dependent manner. In addition, MPC also inhibited the passive cutaneous anaphylaxis activated by anti-dinitrophenyl (DNP) IgE antibody dose dependently. Furthermore, MPC decreased the phorbol 12-myristate 13-acetate plus calcium ionophore A23187-stimulated tumor necrosis factor-alpha and interleukin-6 secretion in human mast cells. These results indicate that MPC may be beneficial in the treatment of immediate-type allergic reactions. |
| 关键词 | 4-arylcoumarins Immediate-type Allergic Reaction Mast Cells Tumor Necrosis Factor-alpha Interleukin-6 |
| DOI | 10.1080/09540100701788636 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000253264700005 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/24971 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Silpakorn Univ, Dept Microbiol, Fac Sci, Nakhon Pathom 73000, Thailand 2.Xiamen Univ, Sch Life Sci, Xiamen, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, Kunming, Peoples R China 4.Chiang Mai Univ, Fac Sci, Dept Biol, Chiang Mai 50000, Thailand |
| 推荐引用方式 GB/T 7714 | Taechowisan, Thongchai,Lu, Chunhua,Shen, Yuemao,et al. 4-arylcoumarin inhibits immediate-type allergy[J]. FOOD AND AGRICULTURAL IMMUNOLOGY,2007,18(3-4):203-211. |
| APA | Taechowisan, Thongchai,Lu, Chunhua,Shen, Yuemao,&Lumyong, Saisamorn.(2007).4-arylcoumarin inhibits immediate-type allergy.FOOD AND AGRICULTURAL IMMUNOLOGY,18(3-4),203-211. |
| MLA | Taechowisan, Thongchai,et al."4-arylcoumarin inhibits immediate-type allergy".FOOD AND AGRICULTURAL IMMUNOLOGY 18.3-4(2007):203-211. |
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| taechowisan2007.pdf（175KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | 浏览 下载 | |
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