Minor dehydrogenated and cleavaged dammarane-type saponins from the steamed roots of Panax notoginseng
Gu, Cheng-Zhen; Lv, Jun-Jiang; Zhang, Xiao-Xia; Yan, Hui; Zhu, Hong-Tao; Luo, Huai-Rong; Wang, Dong; Yang, Chong-Ren; Xu, Min; Zhang, Ying-Jun
2015-06-01
Source PublicationFITOTERAPIA
Volume103Pages:97-105
AbstractNine new minor dehydrogenated and cleavaged dammarane-type triterpenoid saponins, namely notoginsenosides ST6-ST14 (1-9) were isolated from the steamed roots of Panax notoginseng, together with 14 known ones. Among them, 5-7 and 21-22 were protopanaxadiol type and the left 18 compounds, including 1-4, 8-20, and 23 were protopanaxatriol type saponins. Their structures were identified by extensive analysis of MS, 1D and 2D NMR spectra, and acidic hydrolysis. Resulted from the side chain cleavage, the new saponins 1 and 2 featured in a ketone group at C-25, and 3-5 had an aldehyde unit at C-23. The known saponins 12,16 and 18 displayed the enhancing potential of neurite outgrowth of NGF-mediated PC12 cells at a concentration of 10 mu M, while 20 exhibited acetyl cholinesterase inhibitory activity, with IC50 value of 13.97 mu M. (C) 2015 Elsevier B.V. All rights reserved.
KeywordPanax Notoginseng Triterpenoid Saponins Pc12 Cells
DOI10.1016/j.fitote.2015.03.014
Indexed BySCI
Language英语
WOS Research AreaPharmacology & Pharmacy
WOS SubjectChemistry, Medicinal ; Pharmacology & Pharmacy
WOS IDWOS:000356738800011
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Cited Times:10[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/24966
Collection植物化学与西部植物资源持续利用国家重点实验室
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GB/T 7714
Gu, Cheng-Zhen,Lv, Jun-Jiang,Zhang, Xiao-Xia,et al. Minor dehydrogenated and cleavaged dammarane-type saponins from the steamed roots of Panax notoginseng[J]. FITOTERAPIA,2015,103:97-105.
APA Gu, Cheng-Zhen.,Lv, Jun-Jiang.,Zhang, Xiao-Xia.,Yan, Hui.,Zhu, Hong-Tao.,...&Zhang, Ying-Jun.(2015).Minor dehydrogenated and cleavaged dammarane-type saponins from the steamed roots of Panax notoginseng.FITOTERAPIA,103,97-105.
MLA Gu, Cheng-Zhen,et al."Minor dehydrogenated and cleavaged dammarane-type saponins from the steamed roots of Panax notoginseng".FITOTERAPIA 103(2015):97-105.
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