Three new prenylated flavonoids from Macaranga denticulata and their anticancer effects

doi:10.1016/j.fitote.2015.04.001

	Three new prenylated flavonoids from Macaranga denticulata and their anticancer effects
	Yang, Da-Song; Li, Zi-Lei; Peng, Wei-Bing; Yang, Yong-Ping; Wang, Xue; Liu, Ke-Chun; Li, Xiao-Li; Xiao, Wei-Lie
	2015-06-01
发表期刊	FITOTERAPIA
卷号	103 页码:165-170
摘要	One rare flavonoid-diterpene heterodimer, denticulatain C (1), one modified geranyl-type side chain substituted flavonoid, denticulatain D (2) and one geranylated flavonoid, denticulatain E (3), as well as 11 known compounds (4-14) were isolated from the fronds of Macaranga denticulate. Their structures were elucidated on the basis of extensive spectroscopic interpretation. Compounds 4 and 8 inhibited the proliferation of A-549 cell line with IC50 values of 48.6 and 20.2 mu g/mL, respectively. Compounds 3, 6, and 8 exhibited significant antiangiogenic activity on a zebrafish model with IC50 values of 9.78, 034, and 2.55 mu g/mL, respectively. (C) 2015 Elsevier B.V. All rights reserved.
关键词	Macaranga Denticulata Euphorbiaceae Flavonoid-diterpene Heterodimer Geranylated Flavonoids Anticancer Effects
DOI	10.1016/j.fitote.2015.04.001
收录类别	SCI
语种	英语
WOS记录号	WOS:000356738800020
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/24964
专题	资源植物与生物技术所级重点实验室
推荐引用方式 GB/T 7714	Yang, Da-Song,Li, Zi-Lei,Peng, Wei-Bing,et al. Three new prenylated flavonoids from Macaranga denticulata and their anticancer effects[J]. FITOTERAPIA,2015,103:165-170.
APA	Yang, Da-Song.,Li, Zi-Lei.,Peng, Wei-Bing.,Yang, Yong-Ping.,Wang, Xue.,...&Xiao, Wei-Lie.(2015).Three new prenylated flavonoids from Macaranga denticulata and their anticancer effects.FITOTERAPIA,103,165-170.
MLA	Yang, Da-Song,et al."Three new prenylated flavonoids from Macaranga denticulata and their anticancer effects".FITOTERAPIA 103(2015):165-170.

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