Anti-inflammatory effects of 4-arylcoumarins in LPS-induced murine macrophage RAW 264.7 cells

doi:10.1080/13880200600896694

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	Anti-inflammatory effects of 4-arylcoumarins in LPS-induced murine macrophage RAW 264.7 cells
	Taechowisan, Thongchai ; Lu, Chunhua ; Shen, Yuemao ; Lumyong, Saisamorn
	2006-11-01
发表期刊	PHARMACEUTICAL BIOLOGY
卷号	44 期号:8 页码:576-580
摘要	This research was undertaken to find the in vitro inflammatory action of 5,7-dimethyloxy-4-p-methoxyl-phenylcoumarin and 5,7-dimethoxy-4-phenylcoumarin produced by Streptomyces aureofaciens CMUAc130. We investigated the effects of 5,7-dimethyloxy-4-p-methoxyl-phenylcoumarin and 5,7-dimethoxy-4-phenylcoumarin not only on the formation of NO, prostaglandin E-2 (PGE(2)), and tumor necrosis factor-alpha (TNF-alpha) but also on inducible nitric oxide synthase and cyclooxygenase-2 (COX-2) in lipopolysaccharide (LPS)-induced murine macrophage RAW 264.7 cells. The data obtained were consistent with the modulation of iNOS enzyme expression. A similar fashion was also observed when LPS-induced PGE(2) release and COX-2 expression were tested. The significant inhibitory effects were shown in concentration-dependent manners. In addition, 5,7dimethyloxy-4-p-methoxylphenylcoumarin and 5,7dimethoxy-4-phenylcoumarin also mildly but significantly reduced the formation of TNF-alpha. These findings support the application of 5,7-dimethyloxy-4-p-methoxylphenylcoumarin and 5,7-dimethoxy-4-phenylcoumarin as anti-inflammatory agents.
关键词	4-arylcoumarins Anti-inflammatory Activity Endophytic Streptomyces Murine Macrophage Raw 264.7 Cells
DOI	10.1080/13880200600896694
收录类别	SCI
语种	英语
WOS记录号	WOS:000241854400003
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/24805
专题	离退休
作者单位	1.Silpakorn Univ, Fac Sci, Dept Microbiol, Pathom 73000, Thailand 2.Xiamen Univ, Sch Life Sci, Xiamen 361005, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, Kunming, Peoples R China 4.Chiang Mai Univ, Fac Sci, Dept Biol, Chiang Mai 50000, Thailand
推荐引用方式 GB/T 7714	Taechowisan, Thongchai,Lu, Chunhua,Shen, Yuemao,et al. Anti-inflammatory effects of 4-arylcoumarins in LPS-induced murine macrophage RAW 264.7 cells[J]. PHARMACEUTICAL BIOLOGY,2006,44(8):576-580.
APA	Taechowisan, Thongchai,Lu, Chunhua,Shen, Yuemao,&Lumyong, Saisamorn.(2006).Anti-inflammatory effects of 4-arylcoumarins in LPS-induced murine macrophage RAW 264.7 cells.PHARMACEUTICAL BIOLOGY,44(8),576-580.
MLA	Taechowisan, Thongchai,et al."Anti-inflammatory effects of 4-arylcoumarins in LPS-induced murine macrophage RAW 264.7 cells".PHARMACEUTICAL BIOLOGY 44.8(2006):576-580.

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