Anti-apoptotic activity of Bak Foong Pills and its ingredients on 6-hydroxydopamine-induced neurotoxicity in PC12 cells

doi:10.1016/j.cellbi.2005.03.025

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	Anti-apoptotic activity of Bak Foong Pills and its ingredients on 6-hydroxydopamine-induced neurotoxicity in PC12 cells
	Jia, RR ; Gou, YL ; Ho, LS ; Ng, CP ; Tan, NH ; Chan, HC
	2005-10-01
发表期刊	CELL BIOLOGY INTERNATIONAL
卷号	29 期号:10 页码:835-842
摘要	Bak Foong Pills (BFP), a traditional Chinese medicine used for centuries for the enhancement of women's health, was shown to display neuro -protective activity in the 1-methyl-4-phenyl-1,2,4,6,-tetrahydro-pyridine (MPTP)-induced mouse model in a previous study. In order to elucidate its mechanism of action, we investigated the anti-apoptotic properties of Bak Foong Pills and its main ingredients, including Panax ginseng, Angelica sinensis, Glycyrrhiza uralensis, and Ligusticum chuanxiong, in the 6-hydroxydopamine (6-OHDA)-treated PC12 cell model. The addition of the neurotoxin could cause significant cell death and reduction of cell proliferation, as shown in the results determined by MTT assay, nitric oxide (NO) measurement and flow cytometric propidium iodine (PI) staining analysis, while pre-treatment of PC 12 cell with either BFP or its main ingredients prevented the toxicity to some degree. In addition, the neurotoxin caused an elevated activation of caspase-3, the key enzyme for activation of the cellular apoptotic cascade, whereas BFP or its main ingredients inhibited the activation of caspase-3. These results strongly indicate that BFP and its main ingredients may provide a useful therapeutic strategy for the treatment of neurodegenerative diseases, such as Parkinson's disease. (c) 2005 International Federation for Cell Biology. Published by Elsevier Ltd. All rights reserved.
关键词	Bak Foong Pills (Bfp) 6-hydroxydopamine (6-ohda) Pc12 Cell Apoptosis Parkinson's Disease
DOI	10.1016/j.cellbi.2005.03.025
收录类别	SCI
语种	英语
WOS记录号	WOS:000232508000001
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/24790
专题	离退休
作者单位	1.Chinese Univ Hong Kong, Dept Physiol, Epithelial Cell Biol Res Ctr, Shatin, Hong Kong, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming, Yunnan, Peoples R China
推荐引用方式 GB/T 7714	Jia, RR,Gou, YL,Ho, LS,et al. Anti-apoptotic activity of Bak Foong Pills and its ingredients on 6-hydroxydopamine-induced neurotoxicity in PC12 cells[J]. CELL BIOLOGY INTERNATIONAL,2005,29(10):835-842.
APA	Jia, RR,Gou, YL,Ho, LS,Ng, CP,Tan, NH,&Chan, HC.(2005).Anti-apoptotic activity of Bak Foong Pills and its ingredients on 6-hydroxydopamine-induced neurotoxicity in PC12 cells.CELL BIOLOGY INTERNATIONAL,29(10),835-842.
MLA	Jia, RR,et al."Anti-apoptotic activity of Bak Foong Pills and its ingredients on 6-hydroxydopamine-induced neurotoxicity in PC12 cells".CELL BIOLOGY INTERNATIONAL 29.10(2005):835-842.

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