INHIBITORY EFFECTS OF CUCURBITANE TRITERPENOIDS ON EPSTEIN-BARR-VIRUS ACTIVATION AND 2-STAGE CARCINOGENESIS OF SKIN TUMORS

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	INHIBITORY EFFECTS OF CUCURBITANE TRITERPENOIDS ON EPSTEIN-BARR-VIRUS ACTIVATION AND 2-STAGE CARCINOGENESIS OF SKIN TUMORS
	KONOSHIMA, T ; TAKASAKI, M ; TATSUMOTO, T ; KOZUKA, M ; KASAI, R ; TANAKA, O ; NIE, RL ; TOKUDA, H ; NISHINO, H ; IWASHIMA, A
	1994-05-01
发表期刊	BIOLOGICAL & PHARMACEUTICAL BULLETIN
卷号	17 期号:5 页码:668-671
摘要	To search for possible anti-tumor-promoters, we carried out a primary screening of 21 cucurbitane triterpenoids using an in vitro assay system. Of these triterpenoids, scandenoside R6 (6), 23,24-dihydrocucurbitacin F (14), 25-acetyl-23,24-dihydrocucurbitacin F (15), 2-O-beta-D-glucopyranosyl-23,24-dihydrocucurbitacin F (17) and cucurbitacin F (18) exhibited significant inhibitory effects on Epstein-Barr virus (EBV) activation induced by the tumor promoter, 12-O-tetradecanoyl-phorbol-13-acetate (TPA). Further, compounds 14 and 17 exhibited remarkable anti-tumor-promotion effects on mouse skin tumor promotion in an in vivo two-stage carcinogenesis test.
关键词	Cucurbitane Triterpenoid Anti-tumor-promoter Two-stage Carcinogenesis Cowania-mexicana Hemsleya-panacis Scandens Hemsleya-carnosiflora
收录类别	SCI
语种	英语
WOS记录号	WOS:A1994NN12800025
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/24774
专题	离退休
作者单位	1.HIROSHIMA UNIV, SCH MED, INST PHARMACEUT SCI, MINAMI KU, HIROSHIMA 734, JAPAN 2.ACAD SINICA, KUNMING INST BOT, KUNMING, PEOPLES R CHINA 3.KYOTO PREFECTURAL UNIV MED, DEPT BIOCHEM, KAMIKYO KU, KYOTO 602, JAPAN
推荐引用方式 GB/T 7714	KONOSHIMA, T,TAKASAKI, M,TATSUMOTO, T,et al. INHIBITORY EFFECTS OF CUCURBITANE TRITERPENOIDS ON EPSTEIN-BARR-VIRUS ACTIVATION AND 2-STAGE CARCINOGENESIS OF SKIN TUMORS[J]. BIOLOGICAL & PHARMACEUTICAL BULLETIN,1994,17(5):668-671.
APA	KONOSHIMA, T.,TAKASAKI, M.,TATSUMOTO, T.,KOZUKA, M.,KASAI, R.,...&IWASHIMA, A.(1994).INHIBITORY EFFECTS OF CUCURBITANE TRITERPENOIDS ON EPSTEIN-BARR-VIRUS ACTIVATION AND 2-STAGE CARCINOGENESIS OF SKIN TUMORS.BIOLOGICAL & PHARMACEUTICAL BULLETIN,17(5),668-671.
MLA	KONOSHIMA, T,et al."INHIBITORY EFFECTS OF CUCURBITANE TRITERPENOIDS ON EPSTEIN-BARR-VIRUS ACTIVATION AND 2-STAGE CARCINOGENESIS OF SKIN TUMORS".BIOLOGICAL & PHARMACEUTICAL BULLETIN 17.5(1994):668-671.

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