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INHIBITORY EFFECTS OF CUCURBITANE TRITERPENOIDS ON EPSTEIN-BARR-VIRUS ACTIVATION AND 2-STAGE CARCINOGENESIS OF SKIN TUMORS
KONOSHIMA, T; TAKASAKI, M; TATSUMOTO, T; KOZUKA, M; KASAI, R; TANAKA, O; NIE, RL; TOKUDA, H; NISHINO, H; IWASHIMA, A
1994-05-01
发表期刊BIOLOGICAL & PHARMACEUTICAL BULLETIN
卷号17期号:5页码:668-671
摘要To search for possible anti-tumor-promoters, we carried out a primary screening of 21 cucurbitane triterpenoids using an in vitro assay system. Of these triterpenoids, scandenoside R6 (6), 23,24-dihydrocucurbitacin F (14), 25-acetyl-23,24-dihydrocucurbitacin F (15), 2-O-beta-D-glucopyranosyl-23,24-dihydrocucurbitacin F (17) and cucurbitacin F (18) exhibited significant inhibitory effects on Epstein-Barr virus (EBV) activation induced by the tumor promoter, 12-O-tetradecanoyl-phorbol-13-acetate (TPA). Further, compounds 14 and 17 exhibited remarkable anti-tumor-promotion effects on mouse skin tumor promotion in an in vivo two-stage carcinogenesis test.
关键词Cucurbitane Triterpenoid Anti-tumor-promoter Two-stage Carcinogenesis Cowania-mexicana Hemsleya-panacis Scandens Hemsleya-carnosiflora
收录类别SCI
语种英语
WOS记录号WOS:A1994NN12800025
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文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/24774
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作者单位1.HIROSHIMA UNIV, SCH MED, INST PHARMACEUT SCI, MINAMI KU, HIROSHIMA 734, JAPAN
2.ACAD SINICA, KUNMING INST BOT, KUNMING, PEOPLES R CHINA
3.KYOTO PREFECTURAL UNIV MED, DEPT BIOCHEM, KAMIKYO KU, KYOTO 602, JAPAN
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KONOSHIMA, T,TAKASAKI, M,TATSUMOTO, T,et al. INHIBITORY EFFECTS OF CUCURBITANE TRITERPENOIDS ON EPSTEIN-BARR-VIRUS ACTIVATION AND 2-STAGE CARCINOGENESIS OF SKIN TUMORS[J]. BIOLOGICAL & PHARMACEUTICAL BULLETIN,1994,17(5):668-671.
APA KONOSHIMA, T.,TAKASAKI, M.,TATSUMOTO, T.,KOZUKA, M.,KASAI, R.,...&IWASHIMA, A.(1994).INHIBITORY EFFECTS OF CUCURBITANE TRITERPENOIDS ON EPSTEIN-BARR-VIRUS ACTIVATION AND 2-STAGE CARCINOGENESIS OF SKIN TUMORS.BIOLOGICAL & PHARMACEUTICAL BULLETIN,17(5),668-671.
MLA KONOSHIMA, T,et al."INHIBITORY EFFECTS OF CUCURBITANE TRITERPENOIDS ON EPSTEIN-BARR-VIRUS ACTIVATION AND 2-STAGE CARCINOGENESIS OF SKIN TUMORS".BIOLOGICAL & PHARMACEUTICAL BULLETIN 17.5(1994):668-671.
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